抗生素联合硫酸镁治疗先兆早产的疗效研究

Therapeutic effect of antibiotics combined with magnesium sulfate in treatment of threatened preterm labor

目的探讨抗生素联合硫酸镁治疗先兆早产的疗效。方法选择妊娠28~33＋6周先兆早产孕妇117例,随机分成两组：研究组60例,连续使用抗生素以及硫酸镁治疗3天;对照组57例,硫酸镁治疗3天,未使用抗生素。检测治疗前、治疗3天后孕妇宫颈阴道分泌物中的胎儿纤维连接蛋白（f FN）和血清中的C-反应蛋白（CRP）,并比较两组孕妇延长孕周成功率及CRP值的差异。结果 1研究组延长孕周成功率为81.67%（49/60）,对照组延长孕周成功率为52.63%（30/57）,两组差异有统计学意义（χ~2=11.23,P〈0.05）;2研究组治疗前55例（91.67%）孕妇CRP值异常,治疗后9例（15.00%）异常;对照组治疗前52例（91.22%）孕妇CRP值异常,治疗后26例（45.61%）异常,研究组效果显著高于对照组（χ~2=7.02,P〈0.05）。结论抗生素联合硫酸镁治疗先兆早产疗效显著,可降低早产率,值得在临床上预防性使用。

Objective To study the therapeutic effect of antibiotics combined with magnesium sulfate in treatment of threatened preterm labor. Methods One hundred and seventeen pregnant women with threatened preterm labor between 28 and 33 46 weeks of gestation were included, and they were randomly divided into two groups： study group （60 cases） treated continually with antibiotics and magnesium sulfate for 3 days and control group （57 cases） treated with magnesium sulfate for3 days but without antibiotics. C-reactive protein （CRY） and fetal fibronectin （fFN） were detected before treatment and after three-day treatment respectively, and the successful rate of prolonging gestational week as well as CRP were compared between two groups. Results The successful rate of prolonging gestational week was 81.67% （49/60） and 52.63% （30/57） in the study group and in the control group, respectively, and the difference was significant （X2 =11.23, P 〈0.05）. In the study group, the CRY value was abnormal in 55 cases （91.67%） before treatment and 9 cases （ 15.00% ） after treatment, while in the control group there were 52 cases （91.22%） and 26 cases （45.61%）, respectively. The effect of the study group was significantly higher than that of the control group （X2 = 7.02, P 〈 0.05 ）. Conclusion Antibiotics combined with magnesium sulfate is useful in the treatment of threatened preterm labor, which can reduce preterm labor rate. It is worthy of preventive annlication in clinics.