尼莫地平联合丁基苯酞对外伤性蛛网膜下腔出血患者脑微循环的影响

Effect of Cerebral Microcirculation by Nimodipine combined with Butyl Phthalide in Patients with Traumatic Subarachnoid Hemorrhage

目的:探究尼莫地平联合丁基苯酞对外伤性蛛网膜下腔出血患者脑微循环的影响。方法:选取我院外伤性蛛网膜下腔出血患者36例,随机分为实验组和对照组,每组18例。对照组给予尼莫地平治疗,实验组给予尼莫地平联合丁基苯酞治疗。观察并比较两组患者治疗前后脑微循环的变化情况。结果:实验组总有效率(88.9%)高于对照组(61.1%),差异有统计学意义(P<0.05);与治疗前相比,两组脑血容量(CBV)、脑血流量(CBF)水平均增高,平均通过时间(MTT)水平降低(P<0.05);与对照组相比,实验组CBV和CBF水平较高,MTT较低(P<0.05);与对照组相比,实验组格拉斯哥昏迷评分(GOS)评分较高、临床并发症发生率较低、6个月病死率较低,差异有统计学意义(P<0.05)。结论:尼莫地平联合丁基苯酞可有效改善外伤性蛛网膜下腔出血患者的脑微循环,提高患者的生存率。

Objective： To investigate the effect of cerebral microcirculation by nimodipine combined with butyl phthalide in patients with traumatic subarachnoid hemorrhage. Methods： A total of 36 cases with traumatic subarachnoid hemorrhage patients from our hospital were collected and randomly divided into experiment group and control group with 18 cases in each group. Patients in the control group were treated by nimodipine injection; patients in the experiment group were treated by nimodipine injection and, butyl phthalide. After treatment 28 days compared the two groups before and after treatment of cerebral microcireulation changed. Results： At the end of the treatment, the total effective rate of the experiment group （88.9%） was higher than the control group （61.1%）, the difference was statistical significance （P〈0.05）; compared with before treatment, the CBV and CBF levels of the two groups were increased, and the MTT level was decreased （P〈0.05）; compared with the control group, the CBV and CBF levels of the experiment group were higher, MTT level was lower （P〈0.05）; compared with the control group, the experiment group of GOS score was higher, the incidence rate of clinical complications were lower, fatality rate of 6 months was lower, the difference was statistical significance （P〈0. 05）. Conclusion： Nimodipine combined with butyl phthalide in the treatment of patients with traumatic subarachnoid hemorrhage can effectively improve the cerebral microcireulation, improve the patient＇s survival.