不同糖耐量人群血清BED锌指蛋白3表达水平及其与代谢相关指标的关系

Serum ZBED3 Levels in Subjects with Different Status of Glucose Tolerance and Its Correlation of the with Metabolism Related Index

目的:探讨不同糖耐量人群血清BED锌指蛋白3(ZBED3)表达水平及其与代谢相关指标的关系。方法:选取2012年1月到2014年3月在我院就医的115例2型糖尿病(T2DM)患者、97例糖耐量异常(IGT)患者及糖耐量正常(NGT的109名健康体检或志愿者,测定其血清中ZBED3的水平,并分析其与相关的代谢指标的关系。结果:女性群体血清ZBED3水平显著高于男性群体(121.3±33.5 pg/m Lvs 113.9±32.9 pg/m L,P=0.02);超重组血清ZBED3水平显著高于非超重组(132.5±31.4 pg/m L vs 111.4±30.2pg/m L,P=0.00);T2DM组血清ZBED3水平显著高于IGT组和NGT组(143.5±31.2 pg/m L vs 123.7±26.4 pg/m L,97.1±20.3pg/m L,P=0.00)。血清ZBED3水平与体重指数、腰围/臀围比值、体脂百分比、舒张压、收缩压、甘油三酯、空腹胰岛素、空腹血糖及Homa-胰岛素抵抗指数呈正相关(P<0.01),与高密度脂蛋白胆固醇成明显负相关(P<0.01);且腰围/臀围比值、体脂百分比、舒张压、甘油三酯、糖化血红蛋白及Homa-胰岛素抵抗指数是影响血清ZBED3水平的独立相关因素。结论:T2DM、IGT患者及超重群体血清ZBED3水平明显上升,且与肥胖和T2DM的发生发展密切相关。

Objective： To evaluate the serum Zinc finger BED domain-containing protein 3 （ZBED3） levels in patients with different glucose tolerance and disscuss the relationships between ZBED3 and metabolism index. Methods： The subjects were divieded into three groups： type 2 diabetes mellitus （T2DM, n=115）, impaired glucose tolerance （IGT, n=97）, and normal glucose tolerance （NGT, n=109）. Serum ZBED3 levels were measured by ELISA. Insulin levels were measured by radioimmunoassy, lipids levels were measured by ELISA. The relationships between plasma ZBED3 levels and physical/biochemical indicators, such as blood pressure,waist hip ratio （WHR）, blood lipid, blood glucose, plasma insulin levels, body mass index （BMI）, glycosylated hemoglobin （HbA1C） and so on were analyzed. Results： Serum ZBED3 levels were significantly higher in women than that in men （121.3±33.5 pg/mL vs 113.9± 32.9 pg/mL, P =0.02）. Significantly higher ZBED3 levels were also observed in overweight patients when compared with lean individuals （132.5±31.4 pg/mL vs 111.4± 30.2 pg/mL, P =0.00）. The serum ZBED3 levels were higher in type 2 diabetes group when compared with IGT and NGT groups （143.5± 31.2 pg/mL vs 123.7± 26.4 pg/mL, 97.1 ± 20.3 pg/ml, P =0.00）. In a combined population of all three groups, there was a significant positive correlation between ZBED3 and BMI, WHR, BF%, SBP, DBP, TG, FBG, Fins, HbA1c, and HOMA-IR （P 〈 0.01）, whilean inverse relationship of ZBED3 with HDL-C （P 〈 0.01）. Moreover,logistic analysis showed that WI-IR, BF%, DBP, TG, HbA1c, and HOMA-IR were independently related to serum ZBED3 level. Conclusions： The serum ZBED3 levels were significantly increased in T2DM, IGT patients and overweight population, and closely related to the development of obesity and T2DM.