摘要
目的:探讨不同糖耐量人群血清BED锌指蛋白3(ZBED3)表达水平及其与代谢相关指标的关系。方法:选取2012年1月到2014年3月在我院就医的115例2型糖尿病(T2DM)患者、97例糖耐量异常(IGT)患者及糖耐量正常(NGT的109名健康体检或志愿者,测定其血清中ZBED3的水平,并分析其与相关的代谢指标的关系。结果:女性群体血清ZBED3水平显著高于男性群体(121.3±33.5 pg/m Lvs 113.9±32.9 pg/m L,P=0.02);超重组血清ZBED3水平显著高于非超重组(132.5±31.4 pg/m L vs 111.4±30.2pg/m L,P=0.00);T2DM组血清ZBED3水平显著高于IGT组和NGT组(143.5±31.2 pg/m L vs 123.7±26.4 pg/m L,97.1±20.3pg/m L,P=0.00)。血清ZBED3水平与体重指数、腰围/臀围比值、体脂百分比、舒张压、收缩压、甘油三酯、空腹胰岛素、空腹血糖及Homa-胰岛素抵抗指数呈正相关(P<0.01),与高密度脂蛋白胆固醇成明显负相关(P<0.01);且腰围/臀围比值、体脂百分比、舒张压、甘油三酯、糖化血红蛋白及Homa-胰岛素抵抗指数是影响血清ZBED3水平的独立相关因素。结论:T2DM、IGT患者及超重群体血清ZBED3水平明显上升,且与肥胖和T2DM的发生发展密切相关。
Objective: To evaluate the serum Zinc finger BED domain-containing protein 3 (ZBED3) levels in patients with different glucose tolerance and disscuss the relationships between ZBED3 and metabolism index. Methods: The subjects were divieded into three groups: type 2 diabetes mellitus (T2DM, n=115), impaired glucose tolerance (IGT, n=97), and normal glucose tolerance (NGT, n=109). Serum ZBED3 levels were measured by ELISA. Insulin levels were measured by radioimmunoassy, lipids levels were measured by ELISA. The relationships between plasma ZBED3 levels and physical/biochemical indicators, such as blood pressure,waist hip ratio (WHR), blood lipid, blood glucose, plasma insulin levels, body mass index (BMI), glycosylated hemoglobin (HbA1C) and so on were analyzed. Results: Serum ZBED3 levels were significantly higher in women than that in men (121.3±33.5 pg/mL vs 113.9± 32.9 pg/mL, P =0.02). Significantly higher ZBED3 levels were also observed in overweight patients when compared with lean individuals (132.5±31.4 pg/mL vs 111.4± 30.2 pg/mL, P =0.00). The serum ZBED3 levels were higher in type 2 diabetes group when compared with IGT and NGT groups (143.5± 31.2 pg/mL vs 123.7± 26.4 pg/mL, 97.1 ± 20.3 pg/ml, P =0.00). In a combined population of all three groups, there was a significant positive correlation between ZBED3 and BMI, WHR, BF%, SBP, DBP, TG, FBG, Fins, HbA1c, and HOMA-IR (P 〈 0.01), whilean inverse relationship of ZBED3 with HDL-C (P 〈 0.01). Moreover,logistic analysis showed that WI-IR, BF%, DBP, TG, HbA1c, and HOMA-IR were independently related to serum ZBED3 level. Conclusions: The serum ZBED3 levels were significantly increased in T2DM, IGT patients and overweight population, and closely related to the development of obesity and T2DM.
出处
《现代生物医学进展》
CAS
2016年第28期5567-5571,共5页
Progress in Modern Biomedicine
关键词
2型糖尿病
糖耐量异常
BED锌指蛋白3
Type 2 diabetes mellitus (T2DM)
Impaired glucose tolerance (IGT)
Zinc finger BED domain-containing protein 3 (ZBED3)