期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

FoxO1对肝脏脂代谢的影响 被引量：6

The Effect of FoxO1 on Hepatic Lipid Metabolism
原文传递
导出
摘要 Fox O1是叉头转录家族O亚族的一员,因其对胰岛素作用起重要的调控作用而被人所熟知,越来越多的研究表明,Fox O1对于肝脏脂质代谢也起重要的调控作用,其作用机制可能是通过上调微粒体甘油三酯转运蛋白(MTP)、载脂蛋白B(Apo B)的表达,从而促进极低密度脂蛋白(VLDL)在肝脏中的合成,增加循环中VLDL含量;Fox O1还可通过促进载脂蛋白CⅢ(Apo CⅢ)的表达,进而抑制脂蛋白酯酶(LPL)活性,减少循环中甘油三酯(TG)分解,导致高甘油三脂血症的发生;同时,Fox O1还能抑制固醇调节元件结合蛋白SREBP-1c表达,抑制脂肪合成。本文主要通过以上几个方面概述了Fox O1与肝脏脂代谢的影响。 FoxO1 is a member of the FoxO family of transcription factor and is known of it＇s important role in insulin action. More and more studies have shown that FoxO1 also plays an important role in liver lipid metabolism. The mechanism may be that Foxol up-regulated the expression of microsomal triglyceride transfer protein （MTP） and Apolipoprotein B （Apo B）, promoted the synthesis of VLDL in hepatic; and also promoting the expression of Apolipoprotein CIII （Apo CIII）, inhibited the activity of lipoprotein lipase （LPL）, thereby reducing triglyceride decomposition; FoxO1 can also inhibit the expression of SREBP-1c, inhibit the synthesis of fat. The effects of FoxO1 on hepatic lipid metabolism through the above several aspects has been summarized in this paper.
作者 董笑克 刘铜华 孙文 邓莉 洪明昭 郭翔宇
机构地区 北京中医药大学东方医院内分泌科 北京中医药大学研究生院 陕西中医药大学
出处 《现代生物医学进展》 CAS 2016年第28期5593-5596,共4页 Progress in Modern Biomedicine
基金 高等学校博士学科点专项科研基金-新教师类(20120013120012) 北京中医药大学创新团队项目(2011-CXTD-19)
关键词 FOXO1 甘油三脂 极低密度脂蛋白 微粒体甘油三酯转运蛋白 FoxO 1 Triglycerides Very low-density lipoprotein Microsomal triglyceride transfer protein
分类号 Q593.1 [生物学—生物化学]
  • 相关文献

参考文献32

  • 1Barthel A, Schmoll D, Unterman T G. FoxO proteins in insulin action and metabolism [J]. Trends in Endocrinology & Metabolism Tem, 2005, 16(4): 183-189.
  • 2Nakae J, Barr V, Accili D. Differential regulation of gene expression by insulin and IGF 1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR [J]. Embo Journal, 2000, 19(5): 989-996.
  • 3Tomizawa M, Kumar A, Perrot V, et al. Insulin inhibits the activation of transcription by a C-terminal fragment of the forkhead transcription factor FKHR: a mechanism for insulin inhibition of insulin-likegrowth factor binding protein- 1 transcription[YJ. Journal of Biological Chemistry, 2000, 275(10): 11538-11538.
  • 4NakaeJ, Kitamura T, Silver D L, et al. The forkhead transcription factor Foxol (Fkhr) confers insulin sensitivity onto glucose-6- phosphatase expression [J]. Journal of Clinical Investigation, 2001, 108(9): 1359-1367.
  • 5Altomonte J, Richter A, Harbaran S, et al. Inhibition of Foxol function is associated with improved fasting glycemia in diabetic mice [J]. American Journal of Physiology - Endocrinology and Metabolism, 2003, 285(4): E718-E728.
  • 6Wiggins D, Gibbons G F. Origin of hepatic very-low-density lipoprotein triacylglycerol : the contribution of cellular phospholipid [J]. Biochemical Journal, 1996, 320(Pt2): 673-679.
  • 7M Mahmood H, Paul R, Xiaoyue P, et al. Microsomal tfiglyceride transfer protein in plasma and cellular lipid metabolism [J]. Current Opinion in Lipidology, 2008, 19(3): 277-284.
  • 8Wetterau J R, Aggerbcck L P, Bouma M E, et al. Absence of microsomal triglyccride transfer protein in individuals with abetalipoproteinemia[J]. Science, 1992, 258(5084): 999-1001.
  • 9Bcrriot-Varoqueaux N, Aggcrbeck L P, Samson-Bouma M, et al. The role of the microsomal triglygeride transfer protein in abetalipoproteinemia [J]. Annual Review of Nutrition, 2000, 20 (1): 663 -697.
  • 10Adama K, Shen Q, German P, et al. FoxO1 mediates insulin- dependent regulation of hepatic VLDL production in mice[J]. Journal of Clinical Investigation, 2008, 118(6): 2347-2364.

同被引文献59

引证文献6

二级引证文献14

现代生物医学进展
2016年 第28期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部