MicroRNA-155在肝脏中的作用

Role of micro RNA-155 in the liver

微小RNA(microRNAs,miRNAs)是一类长约22个碱基的非编码小RNAs,广泛存在于真核生物,在进化上具有高度保守性、时序性和组织特异性,主要通过与mRNAs的3'-UTR区完全或不完全性结合,影响基因表达的转录和转录后调节,调节不同细胞的增殖,凋亡和分化.微小RNA-155(microRNA-155,miR-155)是miRNAs家庭的典型代表,miR-155功能的表达或异常不仅影响炎症及自身免疫性疾病的发展,而且对肿瘤的增殖和凋亡等发挥重要作用.近年来发现,miR-155在肝脏的分化、形态和功能的维持中发挥重要作用,与肝脏疾病的发生发展、诊断及治疗相关.

MicroRNAs（miRNAs） are a class of endogenous non-coding small RNAs of 22 nucleotides in length that are found in most eukaryotes.Although miRNAs are highly evolutionally conserved,they show temporal and tissue specificity.They transcriptionally and posttranscriptionally regulate gene expression by completely or imperfectly base pairing with the 3＇ untranslated region（3＇-UTR） of target mRNAs and modulate cell proliferation,apoptosis and differentiation.MicroRNA-155（miR-155） is a typical representative miRNA,and abnormal expression or dysfunction of miR-155 function not only affects the development of inflammation and autoimmune diseases,but also plays an important role in tumor proliferation and apoptosis.In recent years,it has been found that miR-155 plays an important role in the differentiation,morphology and function of the liver,and is associated with the development,diagnosis and treatment of liver diseases.