局部药物在治疗种植体周围病中的临床疗效观察

Clinical Effect on Treating peri-implantitis with Local Antibacterial Administration

目的:观察盐酸米诺环素和碘甘油在治疗种植体周围病的临床疗效。方法:将16例种植体周围病病例随机分为对照组8例和实验组8例,对照组给予10%碘合剂牙周留置,实验组采用盐酸米诺环素治疗,观察时间点为治疗前(基线)、治疗后1、4、8周,观察指标为菌斑指数、探诊深度和龈沟出血指数。结果:两种药物对缓解种植体周围病的临床症状都是有效的(P<0.05),两者之间也存在统计学差异(P<0.05),盐酸米诺环素软膏的效果更优于碘甘油。结论:盐酸米诺环素可以有效缓解种植体周围病症状,推荐临床使用。

Objective： To observe clinical effect of minocycline hydrochloride and iodine glycerin on the treatment of peri-implantitis. Methods： 16 peri-implantitis cases were randomly divided into control group （8 cases） and observation group （8 cases）. The control group was given 10% iodine mixture on periodontal indwelling, while the observation group was given minocycline hydrochloride. Before treatment and in the 1st, 4th and 8th weeks after treatment, two groups were respectively collected the changes of plaque index, probing depth and sulcus bleeding index. Results： Both treatments are effective to decrease symptoms （P〈0.05）, and there exists statistical differences （P〈0.05）, but effect of minocycline hydrochloride was superior to that of 10% iodine glycerol. Conclusion： Minocycline hydrochloride could be recommended to treat peri-implantitis due to its good antibacterial effect.