更昔洛韦眼用凝胶与阿昔洛韦滴眼液治疗126例单疱性病毒性角膜炎的临床疗效比较

Clinical curative effect comparison of ganciclovir ophthalmic gel and aciclovir eye drops in treatment of herpes simplex keratitis of 126 cases

目的比较单疱性病毒性角膜炎中应用更昔洛韦眼用凝胶与阿昔洛韦滴眼液的疗效,以探索最佳治疗措施。方法选择我科收治的126例单疱性病毒性角膜炎患者,分为两组,即观察组予以更昔洛韦眼用凝胶治疗,对照组阿昔洛韦滴眼液治疗,每组各63例。治疗后观察不同程度患者的治疗时间,评定疗效及安全性,随访1年观察复发情况。结果本研究中的所有患者均完成治疗,与观察组有效率95.24%比较,对照组有效率降低明显,差异具统计学意义(P<0.05)。与对照组比较,观察组不同病情患者的治疗时间,浅层型、深层型以及混合型的治疗时间均缩短明显,不良反应发生率以及复发率均降低明显,差异可见统计学意义(P<0.05)。结论在单疱性病毒性角膜炎患者中应用更昔洛韦可缩短不同程度患者的治疗时间,疗效较好,且安全性较高,复发率低。

Objective To compare curative effect of ganciclovir ophthalmic gel and aciclovir eye Drops in treatment of herpes simplex keratitis, in order to explore the best treatment measures. Methods 126 cases of herpes simplex keratitis patients treated in our department were selected as research objects, and divided into 2 groups, just as observation group and control group, 63 cases in each group oph pati Patients in observation group were adopted ganciclovir thalmic gel, and patients in control group were adopted aciclovir eye drops. After treatment, different level ents＇ treatment time, efficacy evaluation and safety, follow up 1 year recrudescence were observed. Results In research, all patients completed treatment, compared with observation group patients＇ efficacy 95.24%, control group patients＇ efficacy obviously decreased, and the differences had statistical significances （P 〈 0.05）. Compared with control group, different level patients＇ treatment time, shallow layer, deep layer and mixed type patients＇ treatment time of observation group were all obviously cut down, adverse reaction rate and recurrence rate were all obviously decreased, and the differences had statistical significances （P〈 0.05）. Conclusion Treated with herpes simplex keratitis by ganciclovir can shorten different level patients＇ curative time, get better curative effect with higher safety and lower recurrence rate.