米非司酮联合米索前列醇清宫术治疗胚胎停止发育的出血量及术后并发症研究

Study on volume of bleeding and postoperative complications of mifepristone combined with misoprostol complete curettage of uterine cavity in treatment of embryos stop developing

目的 研究米非司酮联合米索前列醇清宫术治疗胚胎停止发育的出血量及术后并发症情况。方法 以2011年11月~2013年12月我院接收的240例胚胎停止发育患者为研究对象,按照住院先后顺序随机分成两组,各120例患者。观察组患者给予米非司酮联合米索前列醇清宫术治疗,对照组给予米索前列醇与清宫术治疗。对比两组患者的手术情况、不良反应以及并发症情况、宫颈软化与宫口扩张效果。结果 观察组患者的手术时间更短、术中出血量更少、胚胎自然排出以及1次清宫成功率更高、宫颈软化及扩张总有效率显著较高,与对照组相比,差异均有统计学意义（P〈0.01）;而与对照组相比,观察组的术后不良反应与并发症发生率有所降低,但差异无统计学意义（P〉0.05）。结论 米非司酮联合米索前列醇清宫术治疗胚胎停止发育有助于降低患者的出血量和并发症,是一种安全高效的临床治疗方式。

Objective To study the volume of bleeding and postoperative complications of mifepristone combined with misoprostol complete curettage of uterine cavity in treatment of embryos stop developing. Methods 240 cases of patients with embryos stop developing cured in our hospital from November 2011 to December 2013 were seleeted as the research objects. According to the hospital sequence, they were randomly divided into observation group and control group with 120 cases in each. Patients in observation group were treated with mifepristone combined with misoprostol complete curettage of uterine cavity, and patients in control group were treated with misoprostol complete curettage of uterine cavity. Operation conditions, adverse reaction and complications, cervix softening and expansion effect of the two groups were compared. Results On the patients of observation group, its operation time was short, and less bleeding during operation, its success rate of embryo natural discharge and 1 palace embryo were higher, and its cervix softening and expansion total effective rate were significantly higher. Compared with control group, the differences were all statistically significant （P 〈 0.01）. But compared with control group, postoperative adverse reaction and complication rates of observation group were decreased. Statistical analysis showed no significant difference （P 〉 0.05）. Conclusion Mifepristone combined with misoprostol complete curettage of uterine cavity in treatment of embryos stop developing could help to reduce the volume of bleeding and complications of patients. It was a safe and efficient way of clinical treatment.