免疫吸附治疗重症系统性红斑狼疮患者的护理研究

Nursing research of immune adsorption in treatment of patients with severe systemic lupus erythematosus

目的探讨免疫吸附治疗重症系统性红斑狼疮患者的护理效果。方法重症系统性红斑狼疮患者92例,行免疫吸附治疗。采用随机数字表法分为两组,对照组46例实施常规护理,观察组46例实施护理干预,于干预前后给予患者狼疮活动指数和健康状况评定量表评价,比较两组检测指标改善情况、住院情况及护理满意度。结果干预后,两组Ig A、Ig G、Ig M、抗ds-DNA、抗核抗体滴度、狼疮活动指数降低。两组C3、C4、生理功能评分、精神健康评分增加。观察组Ig A、Ig G、Ig M、抗ds-DNA、抗核抗体滴度、狼疮活动指数低于对照组。观察组C3、C4、生理功能评分、精神健康评分、护理满意度高于对照组。观察组住院时间、住院费用少于对照组(P<0.05)。结论免疫吸附治疗重症系统性红斑狼疮的疗效显著,护理干预有助于提高治疗效果。

Objective To investigate nursing effect of immune adsorption in treatment of patients with severe systemic lupus erythematosus. Methods 92 cases of patients with severe systemic lupus erythematosus were selected and treated with immune adsorption. Patients were divided into two groups by random number table method. 46 patients were divided into control group amt received routine nursing. 46 patients were divided into observation group and received nursing intervention. Lupus activity index and health status rating scale were evaluated before and after the intervention. Improvement of detection indexes, hospitalization, and nursing between two groups were compared. Results After intervention, lgA, IgG, IgM, anti-ds-DNA, anti-nuclear antibody titer, lupus activity index were decreased in two groups. C3, C4, physiological function score, mental health score were increased in two groups. IgA, lgG, IgM, anti-ds-DNA, anti-nuclear antibody titer, lupus activity index in observation group were lower than those in control group. C3, C4, physiological function score, mental health score, nursing satisfaction in observation group were higher than those in control group. Hospitalization time and hospitalization expenses in observation group were less than those in control group（P 〈 0.05）. Conclusion Immune adsorption has significant effect in treatment of severe systemic lupus erythematosus. Nursing intervention is helpful to imnrove theraneutic effect.