HPV16／18蛋白表达与新疆维、汉民族头颈部鳞癌患者临床病理特征及预后的相关性

Correlation between HPV16/18 Protein Expression and Clinicopathologic Features and Prognosis in Patients of Uygur and Han nationalities in Xinjiang with Head and Neck Squamous Cell Carcinoma

[目的]探讨HPV16／18蛋白表达与新疆维、汉民族头颈部鳞癌患者临床病理特征及预后的关系。[方法]检测汉族和维吾尔族头颈鳞癌患者各30例癌组织中HPV16／18的蛋白表达水平，分析其与临床病理特征和预后的关系。[结果]汉族人群组织中HPV16／18蛋白表达阳性率显著高于维族（70．0％VS37．7％，P〈0.05）。维族头颈鳞癌患者癌组织中HPV16／18蛋白表达情况与吸烟史、肿瘤分期、病理分级和淋巴结转移有关（均P〈0．05）。汉族患者表达与吸烟史、饮酒史、肿瘤分期和淋巴结转移有关（均P〈0．05）。维族头颈鳞癌患者的预后与肿瘤分期、淋巴结转移和HPV16／18蛋白表达情况有关均（P〈0．05）。汉族患者的预后与吸烟史、淋巴结转移和HPV16／18蛋白表达情况有关（均P〈0．05）。[结论]HPV16／18蛋白表达与新疆维、汉民族头颈部鳞癌患者临床病理特征及预后有关，可作为治疗和预后评估的重要指标。

[Objective]To investigate the correlation between HPV16/18 protein expression and clinicopathological features and prognosis in patients of Uygur and Han nationalities in Xinjiang with head and neck squamous cell carcinoma. [Methods]Thirty cases of Uygur patients with head neck squamous cell carcinoma and thirty cases of Han patients with head neck squamous cell carcinoma were selected in the study. The expression levels of HPV16/18 in the tissues of head and neck squamous cell carcinoma were detected and the relationship between HPV16/18 protein expression and clinicopathological features and prognosis in patients with head and neck squamous cell carcinoma was analyzed. [Results]The positive rate of HPV16/18 protein expression in Han populations was significantly higher than that of Uygur populations in the tissues of head and neck squamous cell carcinoma （70% VS 37.7%, P 〈0.05）. In Uygur populations, HPV16/18 expression in the tissues of head and neck squamous cell carcinoma was associated with smoking history, tumor stage, pathological grading and lymph node metastasis （LNM） （ P 〈0.05）. In Han populations, HPV16/18 protein expression in the tissue of head and neck squamous cell carcinoma cancer was associated with smoking history, drinking history, tumor stage and LNM （ P〈0.05）. The prognosis of patients with head and neck squamous cell carcinoma in Uygur populations was related to tumor stage, LNM and the expression of HPV16/18 protein （ P 〈0.05）. The prognosis of patients with head and neck squamous cell carcinoma in Han populations was related to smoking history, LNM and the expression of HPV16/18 protein （ P %0.05）. [Conclusion]The expression of HPV16/18 protein is related to the clinicopathological characteristics and prognosis of patients with head and neck squamous cell carcinoma in Uygur and Han nationalities in Xinjiang, which can be used as an important index for clinical treatment and prognosis evaluation for patients.