摘要
[目的]探讨秋水仙碱对阵发性心房颤动（房颤）导管消融术后早期复发及炎性因子的影响。[方法]将80例行导管消融术的阵发性房颤患者，随机分为两组：观察组40例给予秋水仙碱；对照组40例为安慰剂对照。观察术后，3个月两组患者复发率，比较消融术前、术后两组间血清高敏-C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）水平的变化。[结果]消融术后，观察组复发率低于对照组（P〈0．05），观察组的hs—CRP及IL-6水平显著低于对照组（P〈0．05），且与术前比较，观察组术后hs—CRP及IL-6水平降低（P〈0．05），对照组术后hs—CRP及IL-6水平较前增高（P〈0．05）。将治疗组进一步分为复发组和未复发组，未复发组hs—CRP及IL-6的术后下降幅度大于复发组（P〈0．05）。[结论]秋水仙碱有助于预防阵发性房颤导管消融术后早期复发，其早期复发率的减少可能与减轻消融术后炎症反应有关。
[Objective]To investigate the effect of colchicine on early recurrence and inflammatory factors after catheter ablation of paroxysmal atrial fibrillation （AF）.[Methods]A total of 80 patients with paroxysmal AF who had received catheter ablation were randomly divided into treatment group （ n=40, colchicine group） and control group （ n = 40, placebo group）.Three month after the ablation treatment, the early recurrence rate of paroxysmal AF were determined. Changes of the serum high sensitivity C-reactive protein （hs-CRP） and interleukin-6 （IL-6）levels were observed before and after the ablation treatment. [Results]After ablation, the recurrence rate of the observation group was lower than that of the control group （ P 〈0.05）. The levels of hs-CRP and IL-6 in the observation group were significantly lower than those in the control group （ P 〈0.05）, and compared with preoperative, postoperative hs-CRP and IL-6 levels were decreased in the observation group （ P〈0.05）, the level of hs-CRP and IL-6 in the control group was higher than that be- fore operation （ P〈0.05）. The treatment group was further divided into recurrent group and non recurrent group, the postoperative recurrence rate of hs-CRP and IL-6 in the non recurrence group was greater than that in the recurrence group （ P〈0.05）.[Conclusion] Colchicine can prevent early recurrence of paroxysmal AF after catheter ablation treatment. This effect seems to be associated with a significant decrease in inflammatory reaction.
出处
《医学临床研究》
CAS
2016年第10期1979-1981,共3页
Journal of Clinical Research
