食管鳞状细胞癌PRL-3及Intβ1表达分析及意义

Expression of phosphatase of regenerating liver-3 and integrin β1 in esophageal squamous cell carcinoma

目的研究促肝细胞再生磷酸酶-3(PRL-3)和整合素β1(Intβ1)在食管鳞状细胞癌中的表达水平及差异,探讨其临床意义。方法采用免疫组织化学法检测40例食管癌患者食管癌组织,癌旁组织和正常组织中PRL-3和Intβ1蛋白的表达水平,利用Image Pro6.0图像分析系统计算平均光密度值(MOD),分析其表达的差异。结果 PRL-3和Intβ1的表达,癌组织中均高于癌旁组织,正常组织中表达最低(P<0.05)。结论 PRL-3和Intβ1在食管鳞状细胞癌组织中表达增高,可作为参考指标判断食管鳞状细胞癌的浸润、转移和预后。

Objective To study expression levels and differences of phosphatase of regenerating liver-3 and integrin β1 protein in esophageal squamous cell carcinoma, and explore its clinical significance. Methods PRL-3 and Intβ1 expression level of esophageal cancer tissue, tissue adjacent to carcinoma and normal tissues were detected by analysis of the differences in expression. Results The protein expressions of PRL-3 and Int β1 in esophageal squamous cell carcinoma were higher than that in the adjacent non-tumor tissues. The protein expressions of PRL-3 and Int β1 were lowest in normal esophageal tissues. Conclusion PRL-3 and Intβ1 may be used as tumor markers in progression, invasion and metastasis of esophageal squamous cell carcinoma.