性激素在风湿性疾病中的研究进展

Research progress of sex hormone in rheumatic diseases

大多数风湿性疾病都存在明显的性别差异;流行病学调查显示,在系统性红斑狼疮(SLE)、类风湿关节炎(RA)、系统性硬化病(SSc)、皮肌炎(DM)等疾病,女性的发病率明显高于男性,而在强直性脊柱炎(AS)、痛风等疾病,则主要为男性受累。临床及实验室已证明,多数风湿性疾病患者的各种病理状态都受到性激素的影响,性激素可能参与了该疾病的发生发展,但具体的作用机制尚不十分清楚。本文就近年性激素在风湿性疾病中的研究进展作一综述。

The most rheumatic diseases have shown significant gender differences. According to epidemiological surveys of some rheumatic diseases such as system lupus erythematosus （SLE）, rheumatoid arthritis （RA）, systemic sclerosis （SSC）, dermatomyositis （DM） etc, female incidence rate was obviously higher than that of male. However, male involvement appears more common in ankylosing spondylitis （AS）, gout and other diseases. Clinical and laboratory investigations have shown that various pathological conditions of the most patients with rheumatic diseases are subject to the influence of sex hormones, so sex hormones may participate in the development and progression of these disease, despite the mechanism is not very clear. This article reviews the recent research progress of sex hormones in rheumatic diseases.