CR1基因多态性对遗忘型轻度认知障碍患者脑功能的影响

Association of CR1 polymorphism with brain function in amnestic-type mild cognitive impairment

目的:探讨补体受体1(CR1)基因rs3818361多态性对遗忘型轻度认知障碍(a MCI)患者脑功能的影响模式。方法:以85例a MCI患者及135例健康对照(HC)者为研究对象,根据CR1 rs3818361基因型分型,采用静息态功能磁共振成像技术,结合多维度认知神经心理量表评估,运用低频振幅算法,分析CR1rs3818361多态性对a MCI患者脑功能的影响。结果:(1)多维度认知神经心理量表功能评分在a MCI组和HC组间的差异有统计学意义(P<0.05)。(2)疾病与基因产生交互作用脑区为右侧额上回(r SFG)及前扣带回(AC)。(3)a MCI组GG基因型患者r SFG和AC的低频振幅值与简易精神状态量表评分呈负相关,与连线测试B所耗时间呈正相关(P<0.002 38)。结论:CR1 rs3818361基因多态性可影响a MCI患者的总体认知功能和执行功能,且局部脑区活动增强可能是对认知功能障碍的代偿。

Objective： Exploring association of complement receptor 1（ CR1） rs3818361 polymorphism with brain resting-state function in amnestic-type mild cognitive impairment（ a MCI） patients. Methods： In this study,85 a MCI patients and 135 healthy controls（ HC） grouped by their CR1 rs3818361 genotypes underwent resting-state functional magnetic resonance and a clinical interview which focused on neurological and mental status. Gene-brainbehavior relationships were examined to determine the effect of the risk variant on regional brain activity in these subjects. Results：（ 1） The difference of neurological and mental status between a MCI and HC subjects was significant（ P〈0. 05）.（ 2） Regions of ＂groups × genotypes＂ANOVA interaction were located in right superior frontal gyrus（ r SFG） and anterior cingulate（ AC）.（ 3） Negative relation of regional brain activity of r SFG and AC with mini-mental state examination（ MMSE）,positive relation of regional brain activity of r SFG and AC with seconds consumed in trail making test B（ TMT-B） were observed in GG carriers of a MCI patients（ P〈0. 002 38）.Conclusion： Our findings are the first to show that CR1 rs3818361 polymorphism has a significant influence on overall cognitive function impairment and executive function,which may be compensated by regional brain hyperactivity.