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缺血性中风证候要素与疾病预后的相关性初探 被引量:15

Preliminary research on the correlation between syndrome factors and disease prognosis of ischemic stroke
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摘要 目的:探讨缺血性中风证候要素与疾病预后的关系。方法:动态采集缺血性中风患者(发病72h以内入组)的入组1、4、7、10、14、21、28d《缺血性中风证候要素诊断量表》(内风、内火、痰湿、血瘀、气虚、阴虚)评分、美国国立卫生研究院卒中量表(NIHSS)得分,以及发病90d生活自理能力评定Barthel指数(BI)得分。应用Logistic回归模型探讨缺血性中风证候要素与疾病指标的关系,并运用Spearman相关性分析对各时点证候要素与NIHSS评分进行相关性分析。结果:入组4、7、10d出现阴虚是预测28d NIHSS减分值的危险因素(B>0,P<0.05,OR>1),入组14、21d出现内风是预测28d NIHSS减分值的危险因素(B>0,P<0.05,OR>1),入组7d出现内火是预测缺血性中风远期预后的危险因素(B>0,P<0.05,OR>1)。内风与NIHSS评分在入组4-21d各时点均存在相关性(P<0.05),入组7d内火与14-28d时点NIHSS评分存在相关性(P<0.05)。结论:缺血性中风急性期出现阴虚对近期预后不利,恢复期出现内风对近期预后不利,急性期出现内火对远期预后不利。 Objective: To explore the correlation between syndrome factors and disease prognosis of ischemic stroke. Methods: The data of ischemic stroke cases which were enrolled within 72 h since disease onset were extracted. Including data of Diagnostic Scale of Syndrome Factors of Ischemic Stroke(endogenous wind, endogenous fire, phlegm-dampness, blood stasis, qi deficiency, yin deficiency) on D1, D4, D7, D10, D14, D21, D28, score of National Institutes of Health Stroke Scale(NIHSS), and score of Barthel Index on D90 since disease onset. Logistic regression was used to investigate the correlation between syndrome factors of ischemic stroke and disease indicator. Then the relationship between syndrome factors and NIHSS score in each time point we analyzed by Spearman Correlation. Results: Yin deficiency on D4, D7, D10 is risk factor of NIHSS deduction value on D28(B〉0, P〈0.05, OR〉1). Endogenous wind on D14, D21 is risk factor of NIHSS deduction value on D28(B〉0, P〈0.05, OR〉1). Endogenous fire on D7 is risk factor of NIHSS in long term prognosis(B〉0, P〈0.05, OR〉1). There was correlation between endogenous wind and NIHSS score during D4-21(P〈0.05), so was between endogenous fire on D7 and NIHSS score during D14-28(P〈0.05). Conclusion: Yin deficiency syndrome in acute phase of ischemic stroke and endogenous wind syndrome in recovery phase are risk factors of short term prognosis, while endogenous fire syndrome in acute phase is a risk factor of long term prognosis.
作者 王少卿 高颖
出处 《中华中医药杂志》 CAS CSCD 北大核心 2016年第11期4794-4797,共4页 China Journal of Traditional Chinese Medicine and Pharmacy
基金 2010年国家公益性行业科研专项(No.201007002)~~
关键词 缺血性中风 证候要素 预后 Ischemic stroke Syndrome factor Prognosis
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