血管生成相关因子在口腔鳞癌中的研究进展

Research advances on angiogenic factors in oral squamous cell carcinoma

肿瘤的发展及转移与血管生成关系密切,当肿瘤生长至一定程度,在多种因子的调节作用下,瘤体通过血管新生从宿主获取生长所需的营养及氧气,转运代谢产物,同时新生血管在一定程度上为肿瘤细胞的转移及扩散创造了条件。近年来,随着肿瘤与血管生成之间研究的不断深入,以抗血管生成为靶点的口腔鳞癌综合序列治疗日益引起重视。本文就影响血管生成的相关因子在口腔鳞癌中的研究现状进行综述。

Tumors′ progression and metastasis is closely correlated with angiogenesis. When tumors grow to a certain size, with the regulating effect of mutiple factors, they form new blood vessels to acquire nutrients and oxygen from hosts to maintain their own growth, meanwhile, the new vessels create conditions for the transfer and diffusion of tumor cells. Recently, with the deepening researches on the relationship between tumors and angiogenesis, the anti-angiogenesis targeted synthetic serial treatment for oral squamous cell carcinoma gradually comes into notice. This review focuses on the current research of angiogenic factors in oral squamous cell carcinoma.