祛风稳斑汤对不稳定型心绞痛(痰瘀互结证)hs-CRP、Hcy、NT-proBNP的影响

Effect of Qufeng Wenban Decoction on Patients with Unstable Angina Due to Syndrome of Phlegm and Blood Stasis and hs-CRP,Hcy,NT-proBNP

目的通过观察祛风稳斑汤治疗不稳定型心绞痛(UA)(痰瘀互结证)的临床疗效。方法将UA痰瘀互结证患者99例,随机分为对照组49例和治疗组50例。对照组使用常规抗心绞痛药常规治疗,治疗组在使用常规抗心绞痛药治疗加上自制祛风稳斑汤。结果治疗组总有效率为90.00%,高于对照组的77.55%(P<0.05)。两组心绞痛持续时间、发作频率治疗前无显著性差异,治疗后均明显降低(P<0.05),且治疗组治疗后与对照组比较有显著性差异(P<0.05)。两组Hcy、hs-CRP、NT-pro BNP水平治疗前无显著性差异,治疗后均明显降低(P<0.05),且治疗组与对照组治疗后比较有显著性差异(P<0.05)。结论祛风稳斑汤对UA(痰瘀互结证)有较好的治疗作用,能显著降低心绞痛持续时间、发作频率。

Objective： To investigate the mechanisms in the treatment of UA due to syndrome of phlegm and blood stasis with Qufeng Wenban Decoction through the observation on its clinical curative effect in the treatment of unstable angina（UA） and its effect on hs-CRP, Hcy and NT-proBNP. Methods： 99 cases of UA in our hospital from 2014.12 to 2015.12 were randomly divided into control group and treatment group with 49 cases in the control group and 50 cases in the treatment group. The control group was treated with conventional anti angina pectoris medicine and the treatment group was treated with conventional anti angina pectoris medicine treatment plus self-made decoction for expelling the wind steady plaque ,taken decocted with water and 100 mL each time, 3 times,oral. The total effective rates of the two groups were observed,and the changes of hs-CRP,Hcy and NT- proBNP before and after the treatment in two groups were detected. Results： The total effective rate of the treatment group was 90.00% and the total effective rate of the control group was 77.55%. The total effective rate of the treatment group was significantly higher than that of the control group,and there was significant difference （P〈 0.05）. There was no significant difference on the angina pectoris continued time and the frequency of attack between the two groups before the treatment. After the treatment, both the indicators got significantly lower in the two groups and it showed significant difference （P〈 0.05） and there was significant difference （P〈 0.05） on the angina pectoris continued time and the frequency of attack between the treatment group and the control group after the treatment. There was no significant difference on the Hcy, hs-CRP and NT proBNP levels before the treatment. After the treatment,the levels got significantly lower in the two groups and it showed significant difference （P〈 0.05） and there was significant difference（P〈 0.05） on the Hcy,hs-CRP and NT proBNP levels between the treatment group and the control group after the treatment. Conclusion： Qufeng Wenban Decoction has good ther- apeutic effect on UA due to syndrome of phlegm and blood stasis and can reduce the angina pectoris continued time and the frequency of attack significantly. The mechanism of Qufeng Wenban Decoction may form effective intervention of coronary atherosclerosis vulnerable plaque,increase plaque stability and prevent cardiovascular events by inhibiting inflammation, anti-platelet aggregation, the protection of endothelial function, etc.