抗γ-氨基丁酸B受体脑炎二例并文献复习

An analysis and literature review of two cases of autoimmune encephalitis with GABAB receptor antibodies

抗γ-氨基丁酸B（GABAB）受体脑炎临床鲜有报道.本研究回顾性分析了2例抗GABAB受体脑炎,2例患者均以癫痫为首发症状,疾病过程中伴发热,症状急性加重或快速进展,随后出现意识水平下降,频繁癫痫发作;病程后期可出现双手节律性振动,以竖毛肌收缩为表现的癫痫发作.脑电图、头颅MRI对诊断该病没有特异性.患者对一线免疫治疗敏感.

Autoimmune encephalitis with GABAB receptor antibodies has been rarely reported.Two cases of GABAB receptor antibodies encephalitis were presented here.Epilepsy was the onset symptom,followed by declined consciousness and frequent seizures.Fever was presented in the whole course of the disease.Myorhythmia of the two hands and pilomotor seizures were shown in the later course of the disease.No specificity was demonstrated in electroencephalograms and magnetic resonance imaging.Sensitive response was shown to the first-line immunotherapy.