妊娠期肝内胆汁淤积症患者肝酶及胆汁酸水平对妊娠结局的影响

Effect of liver enzymes and bile acid levels on pregnancy outcome in patients with intrahepatic cholestasis of pregnancy

目的 探讨妊娠期肝内胆汁淤积症患者肝酶、胆汁酸对妊娠结局影响.方法 随机选取2012年6月2014年6月肝内胆汁淤积症产妇50例为观察组,选取同期正常妊娠产妇50例为对照组,分析肝酶、胆汁酸水平与妊娠结局的相关性.结果 50例肝内胆汁淤积症产妇血清胆汁酸水平越高,羊水粪染越严重,两者呈正相关（P〈0.05）.7例窒息新生儿血清总胆汁酸水平≥40.0μmol/L,其羊水粪染程度为Ⅱ-Ⅲ度6例（85.7％,6/7）,胆汁酸水平与妊娠结局呈正相关.结论 妊娠期肝内胆汁淤积症患者肝酶指标、胆汁酸指标升高会严重影响胎儿的预后.

Objective To investigate the effect of liver enzymes and bile acid levels on pregnancy outcome in patients with intrahepatic cholestasis of pregnancy.Methods From June 2012 to June 2014,50 pregnant women with intrahepatic cholestasis of pregnancy were randomly selected as observation group,50 cases of normal pregnancy in same period were selected as control group,the correlation of liver enzyme,bile acid level with pregnancy outcome were analyzed.Results The higher serum bile acid level in the observation group,the more serious meconium stained amniotic fluid,there was positive correlation（P 〈 0.05）.The serum total bile acid level of seven asphyxia neonatal was higher than 40.0 μrnol/L,six cases of meconium stained amniotic fluid of dye were Ⅱ-Ⅲ （85.7%,6/7）.Bile acid levels were positively correlated with pregnancy outcomes.Conclusions Liver enzyme indicators,bile acid indicators ascension in patients with intrahepatic cholestasis of pregnancy have serious effect on the embryo prognosis.