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肝细胞粘附分子在膀胱移行细胞癌中的表达及意义

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摘要 目的 通过检测肝细胞粘附分子(hepaCAM)基因在膀胱移行细胞癌(TTCCB)组织中的表达,探讨其在膀胱癌发病中的分子机制.方法 选取TCCB组织15例为TCCB组,正常膀胱组织10例为对照组.以实时定量聚合酶链反应(RT-PCR)法检测膀胱组织hepaCAM mRNA表达;Western印迹法检测hepaCAM蛋白表达.比较两组hepaCAM mRNA及蛋白表达的差异.结果 与正常膀胱组织比较,TCCB组织hepaCAM mRNA及蛋白表达均明显降低,差异有统计学意义(P〈0.05).结论 hepaCAM基因低表达可能是TCCB发病潜在分子机制.
作者 冯建强
出处 《中国实用医刊》 2016年第19期102-104,共3页 Chinese Journal of Practical Medicine
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