大株红景天联合胰激肽原酶治疗早期糖尿病肾病的临床分析

Clinical observation on the effect of rhodiola kirilowii regel combined with kallidinogenase in treatment of early diabetic nephropathy

目的 探讨大株红景天联合胰激肽原酶治疗早期糖尿病肾病的临床疗效.方法 选择50例早期糖尿病肾病患者,随机分成治疗组和对照组,每组25例.两组均给予合理饮食与运动,积极控制血糖、血脂、血压等,对照组给予胰激肽原酶40 U肌肉注射,每日1次;治疗组在此基础上加用大株红景天注射液10 ml溶于5％葡萄糖注射液250 ml中滴注,并且加入普通胰岛素3U,每日1次,10d为1个疗程.比较两组患者治疗前后血肌酐（Scr）、尿素氮（BUN）及24 h尿白蛋白排泄率（UAER）指标.结果 两组UAER均下降（P 〈0.05或P〈0.01）,尤以治疗组更明显（P〈0.05）,BUN和Scr两组均无明显变化.治疗组有效率为92.0％,明显高于对照组的68.0％ （P〈0.05）.结论 大株红景天联合胰激肽原酶治疗早期糖尿病肾病效果肯定.

Objective To investigate the clinical effect of rhodiola kirilowii regel combined with kallidinogenase on early diabetic nephropathy.Methods Fifty patients with early diabetic nephropathy were randomly divided into treatment group and control group,with 25 cases in each group.Two groups were given a proper diet and exercise,the positive control of blood glucose,blood lipid and blood pressure.Patients in control group were given 40 U intramuscular injection of pancreatic kininogenase,1 time a day.On the basis of control group,the patients in treatment group were given rhodiola kirilowii regel injection （10 ml） dissolved in 5% glucose injection 250 ml infusion,and joined the regular insulin 3 units,once a day,10 days for a course of treatment.Blood creatinine （Scr）,urea nitrogen （BUN） and 24 h urinary albumin excretion rate （UAER） were compared between the two groups before and after treatment.Results UAER in the two groups decreased （P 〈 0.05 or P 〈 0.01）,especially in the treatment group was more significant （P 〈 0.05）,BUN and Scr of two groups had no significant change.The effective rate of the treatment group was 92%,which was significantly higher than that of the control group （68%,P 〈 0.05）.Conclusions Effect of Rhodiola kirlowii Regel combined with kallidinogenase on early diabetic nephropathy is significant.