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ATGL生化功能调节及与心肌肥厚的关系

Regulation of ATGL Activity and the Relation to Cardiac Hypertrophy
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摘要 脂肪甘油三酯脂肪酶是脂肪分解代谢限速酶,ATGL广泛表达于全身各组织,尤其高表达于脂肪组织、肝脏和心脏等.ATGL敲除显示动物因大量甘油三酯堆积而产生严重肥胖,心脏受累尤其严重.主要介绍ATGL功能调节及其功能失调与心肌肥厚的关系. Adipose triglyceride lipase （ATGL） is the rate-limiting enzyme of TG hydrolysis. There is high expression in adipose, liver, heart,and so on. ATGL knockout can result in bulks of triglyceride accumu-lation and induce significant cardiac hypertrophy in mice or rats. This review focuses on the regulation of ATGL activity and expression and how its dysfunction results in cardiac hypertrophy.
作者 彭英福 高辉
机构地区 吉首大学医学院
出处 《吉首大学学报（自然科学版）》 CAS 2016年第5期85-90,共6页 Journal of Jishou University(Natural Sciences Edition)
基金 国家自然科学基金资助项目(81560059) 湖南科技厅科技计划资助项目(2013SK3179) 吉首大学博士科研启动基金资助项目(JSDXXCFXBSKYXM201505)
关键词 ATGL 甘油三酯 心肌肥厚 ATGL triglyceride cardiac hypertrophy
分类号 R363.2 [医药卫生—病理学]
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参考文献56

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二级参考文献11

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吉首大学学报（自然科学版）
2016年 第5期

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