被动吸烟与舌癌的病例对照研究

Association between passive smoking and tongue cancer: a case-control study

目的探讨被动吸烟与舌癌发病的关系。方法采用病例对照研究方法，收集2010年9月-2015年1月经病理确诊的舌癌新发病例190例，并选取同期686例社区健康人群作为对照。应用非条件Logistic回归模型估算仅18岁前、仅18岁后、18岁前后均被动吸烟与舌癌发病风险的调整OR（95％CI）值，并进一步对性别、年龄进行分层分析。结果与无被动吸烟者相比，仅18岁前被动吸烟可增加舌癌的发病风险为2．813（OR=2．813，95％a：1．581～5．005），仅18岁后被动吸烟可增加舌癌的发病风险为1．666（OR=1．666，95％CI：I．055～2．631）；18岁前后均被动吸烟可增加舌癌的发病风险为2．690（OR=2．690，95％CI：1．674～4．322）。而且每日暴露时间越长、开始暴露年龄越小、被动吸烟年限越长，患舌癌的危险性就越大（均有P＆#〈0．05）。分层分析结果显示在被动吸烟人群中，女性或年龄960岁者比男性或年龄〈60岁者患舌癌的风险更高。结论被动吸烟是舌癌发病的危险因素，减少被动吸烟可在一定程度上降低舌癌的发生。

Objective To investigate the association between passive smoking and tongue cancer in residents in Fujian Province. Methods A case-control study was performed including 190 tongue cancer cases with pathologically con- firmed and 686 community controls from September 2010 to January 2015. Unconditional logistic regression analysis was used to estimate adjusted odds ratios （ORs） between passive smoking and tongue cancer, and their corresponding 95% confidence intervals （CIs）. Stratified analysis was carried out on the sex, age, and residence to explore possible difference in association between subgroups. Results Passive smoking was positively associated with the risk of tongue cancer; ad- justed ORs were 2. 813 （95% CI： 1. 581-5. 005） for those only initiated before the age of 18, 1. 666 （95% CI： 1. 055- 2. 631 ） for those only initiated after the age of 18, and 2. 690 （95% CI： 1. 674-4. 322） for those both initiated before and after the age of 18. With the decrease in the initiated age and increase in daily exposure duration as well as duration of passive smoking, the risk of tongue cancer was elevated （all Ptrend 〈 0.05 ）. Stratified analysis indicated that passive smokers in female or in people aged 60 and over had higher risk of tongue cancer, compared with those in male or in people aged under 60. Conclusions Passive smoking is an independent risk factor for tongue cancer. Avoiding passive smoking could reduce the incidence of tongue cancer to a certain extent.