中国原发性胆汁性胆管炎的诊治现状和挑战

Current status of diagnosis and treatment of primary biliary cholangitis and related challenges in China

原发性胆汁性胆管炎最早被命名为原发性胆汁性肝硬化,是一种慢性胆汁淤积性肝病,其特点是免疫介导的中小胆管的破坏。近些年,随着人们对该病认识的不断提高,新型免疫学与病理学检测技术的广泛应用,我国在该病的诊断和治疗等方面逐渐与国际接轨,同时也取得了一系列具有创新性的临床研究发现和成果。对上述成果进行全面的综述,并提出未来我国将要面临的相关挑战及可能的应对措施。

Primary biliary cholangitis,once named primary biliary cirrhosis,is a chronic cholestatic liver disease characterized by immune-mediated damage of small and medium-sized bile ducts. Recently,with the improvement in the knowledge of this disease and the wide application of new immunological and pathological detection techniques,the gap between China and Western countries in the diagnosis and treatment of PBC has been gradually narrowed,and a series of innovative findings and results have also been achieved. This article reviews these achievements and points out future challenges and possible solutions.