慢性HBV感染的天然免疫与获得性免疫应答

Innate immune response and acquired immune response in patients with chronic HBV infection

HBV感染人体后,宿主的抗病毒免疫应答是决定感染结局的关键因素。目前普遍认为,在慢性HBV感染过程中宿主的天然免疫及获得性免疫功能受损,从而导致病毒持续无法清除。要实现对HBV感染持久免疫控制,需要更加全面地理解HBV感染慢性化引起的机体天然免疫和特异性免疫应答功能障碍的机制。总结了国内外研究团队在HBV感染慢性化免疫应答参与机制中取得的进展。

After the infection with HBV,the host＇s antiviral immune response is a key factor for the outcome of infection. At present,it is widely believed that the host＇s innate immunity and acquired immunity are impaired during chronic HBV infection,because of which HBV clearance cannot be achieved. To achieve a long-lasting immune control of HBV infection,we need to comprehensively understand the mechanisms of dysfunction of innate immune response and specific immune response in chronic HBV infection. This article summarizes the research advances in the immune response mechanism of chronicity of HBV infection.