自身免疫性肝炎免疫学治疗进展被引量：7

Advances in immunological treatment of autoimmune hepatitis

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摘要近年来自身免疫性肝炎(AIH)以其独特的临床和病理学特征,受到越来越多的关注。但目前其发病率和临床特征仍不十分清楚,尚需对其进行系统深入的研究。探讨了AIH的流行病学、病因和发病机制、临床特征及其诊断和治疗进展。指出TNFα中和性抗体、利妥昔单抗、全反式维甲酸和调节性T淋巴细胞移植在临床试验或AIH动物模型中均被证明对AIH有疗效。 In recent years,autoimmune hepatitis（ AIH） has attracted more and more attention due to its unique clinicopathological features. However,its incidence and clinical features remain unclear,and systematic and in-depth studies are still needed. This article reviews the epidemiology,etiology,pathogenesis,clinical features,and diagnosis and treatment of AIH and points out that clinical studies or animal models of AIH have proved the effects of TNF-α neutralizing antibody,rituximab,all-trans retinoic acid,and regulatory T cell transplantation in the treatment of AIH.

作者张珺王绮夏马雄

机构地区上海交通大学医学院附属仁济医院消化内科

出处《临床肝胆病杂志》 CAS 2016年第10期1874-1877,共4页 Journal of Clinical Hepatology

关键词肝炎自身免疫性免疫学治疗 hepatitis autoimmune immunology therapy

分类号 R575.1 [医药卫生—消化系统]

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