循环血microRNA在肝纤维化发生发展中的作用

Role of circulating microRNAs in development and progression of liver fibrosis

MiroRNA(miRNA)可通过外泌体等载体分泌,游离于细胞之外,并可在循环血液中保持稳定状态。目前研究表明,循环血中miRNA的变化趋势与疾病的不同病理状态相关,提示循环血中miRNA可作为疾病潜在的诊断和治疗分子靶标。研究表明多种miRNA与肝纤维化的发生发展密切相关,概述了目前关于肝纤维化进程中循环血miRNA表达差异的研究,多种研究提示循环血miRNA可为肝纤维化的无创性早期诊断和治疗提供新的研究方向。

Recent studies have found that microRNAs（ miRNAs） can be secreted via exosomes,stay outside the cells,and keep stable in circulating blood. Various studies have shown that the changes in circulating miRNAs are associated with different pathological states,suggesting that the circulating miRNAs can be used as potential molecular targets for the diagnosis and treament of diseases. Research has shown that miRNAs are closely associated with the development and progression of liver fibrosis. This article reviews the studies on the differences in the expression of circulating miRNAs in the course of liver fibrosis and points out that circulating microRNAs can provide a new research direction for early noninvasive diagnosis and treatment of liver fibrosis.