肝硬化并发静脉血栓栓塞的研究进展

Research advances in venous thromboembolism in patients with liver cirrhosis

传统观点认为肝硬化常伴有出血倾向,主要与凝血因子减少、纤溶亢进、血小板减少及门静脉压力增高有关。也有研究认为肝硬化处于高凝状态,易发生静脉血栓栓塞,严重影响预后。概述了肝硬化并发静脉血栓栓塞的流行病学特征、危险因素及静脉血栓栓塞预防的意义,以供指导临床实践。

Traditionally,liver cirrhosis has a bleeding tendency due to the reduction in blood coagulation factors,hyperfibrinolysis,thrombocytopenia,and increased portal hypertension. Some studies show that the patients with live cirrhosis are in a state of hypercoagulability and tend to develop venous thromboembolism,which greatly affects the patients＇ prognosis. This article reviews the epidemiological features and risk factors of venous thromboembolism,as well as the significance of prevention of venous thromboembolism in patients with liver cirrhosis,so as to guide clinical practice.