细胞自噬在心血管疾病发病过程中的作用

The Role of Autophagy in Developments of Cardiovascular Diseases

心血管疾病是一类危害心脏和血管功能的疾病,其发病是一个复杂的病理生理过程。细胞自噬(autophagy)是一种广泛存在于真核细胞、进化上高度保守的细胞降解过程。饥饿、缺血、氧化应激等均可诱导其发生。自噬在细胞的生长、代谢、死亡等过程中起至关重要的作用,也参与了多种疾病的发生。近期发现,自噬与心血管疾病的发生、发展密切相关。正常的细胞自噬对心肌细胞有保护作用,自噬不足或自噬过度则可促发疾病或加重病变,本文对细胞自噬在心血管疾病发病中的作用做一综述。

Cardiovascular disease is a class of diseases that involve the heart or blood vessels. The initiation and development of cardiovascular diseases involve complicated pathophysiological processes. Autophagy is a highly conserved intracellular degradation process in eukaryotic cells. It is usually induced by starvation,ischemia and oxidative stress. Autophagy plays critical roles in cell proliferation,metabolism,and cell death. Autophagy also involved in developments of many diseases. Recently,it was reported that autophagy was related to the initiation and development of cardiovascular diseases. The physiological level of autophagy protected cardiac muscle cells,whereas the deficient or excessive autophagy should induce or aggravate cardiovascular diseases. In this review paper,we make a summary of the role of autophagy in the pathogenesis of cardiovascular diseases.