120例氟喹诺酮类药物所致不良反应的临床特点研究

Clinical Characteristics of 120 Cases of Fluoroquinolone-induced Adverse Reactions

目的研究氟喹诺酮类药物在临床治疗过程中出现的不良反应情况,为临床合理用药提供指导。方法回顾性分析我院2014年9月到2016年1月间使用氟喹诺酮类药物患者并出现不良反应（ADR）患者共120例,统计所有患者的性别、年龄等一般资料,比较患者使用药物种类和ADR表现形式,比较两组患者的给药方式。结果男性患者的ADR发生率明显高于女性患者（P〈0.01）,年龄在31~50岁的患者的ADR发生率比例明显高于其他年龄段患者（P〈0.05）,患者发生中枢神经系统ADR、胃肠道ADR、皮肤、ADR发生率较其他ADR高（P〈0.05）,患者年龄大其ADR发生时间和恢复时间明显高于年纪小患者（P〈0.05）。结论氟喹诺酮类药物在临床治疗过程中容易产生各类不良反应,好发于男性及中年人群中,同时引起氟喹诺酮类药物所致的ADR因素有许多,临床治疗过程中应密切观察患者ADR,选择最合适的治疗方案有利于控制ADR发生。

OBJECTIVE To study the fluoroquinolones appear in the clinical course of treatment adverse reactions, provide guidance for clinical therapy. METHODS A retrospective analysis of our hospital from September 2014 to January 2016 the use of fluoroquinolones in patients with medication and adverse reactions（ ADR） in patients with a total of 120 cases,statistics in all patients by sex,age and other general information,compare patients using drugs types and forms of ADR, two groups were compared administration. RESULTS ADR incidence of male patients than female patients（ P〈0. 01）,age ADR incidence ratio of31 to 50 year-old patient was significantly higher than other age groups of patients（ P〈0. 05）,patients with central nervous system ADR,gastrointestinal tract andskin and accessories ADR ADR ADR than other high incidence（ P〈0. 05）,patients older its ADR occurrence time and recovery time was significantly higher than younger patients（ P〈0. 05）. CONCLUSION The clinical course of fluoroquinolones in the treatment of various types prone to adverse reactions,occurs in men and middle-aged population,while causing ADR fluoroquinolone-induced factors There are many clinical course of treatment should be closely observed in patients ADR,choose the most appropriate treatment options help control the occurrence of ADR.