COPD患者血清白细胞介素6、超敏C-反应蛋白、白细胞介素10的检测及意义

The detection and significance of serum IL-6,hs-CRP,IL-10 in chronic obstructive pulmonary disease patients

目的探讨慢性阻塞性肺疾病(COPD)患者血清白细胞介素6(IL-6)、超敏C-反应蛋白(hs-CRP)和白细胞介素10(IL-10)的检测及意义。方法收集34例COPD急性加重期患者、34例COPD稳定期患者和34例健康志愿者,分别设为急性组、稳定组、对照组。检测各组血清IL-6、hs-CRP、IL-10水平,分析其与肺功能指标的相关性。结果急性组和稳定组FEV1百分比、FEV1/FVC显著低于对照组,而急性组FEV1百分比、FEV1/FVC显著低于稳定组,两两比较差异均有统计学意义(P<0.05)。急性组和稳定组hs-CRP、IL-6显著高于对照组,IL-10显著低于对照组,而急性组hsCRP显著高于稳定组,IL-10显著低于稳定组,两两比较差异均有统计学意义(P<0.05)。Pearson相关分析显示,COPD患者血清IL-6、hs-CRP与FEV1百分比、FEV1/FVC均呈负相关(r值分别为-0.221,-0.216,-0.386,-0.369,P<0.05),而血清IL-10与FEV1百分比、FEV1/FVC均呈正相关(r值分别为0.318,0.297,P<0.05)。结论 IL-6、hsCRP、IL-10参与了COPD的发病,且一定程度反应了疾病的严重程度。

Objective To explore the detection and significance of serum interleukin 6（ IL- 6）,high- sensitivity C- reactive protein（ hs- CRP） and interleukin 10（ IL- 10） in chronic obstructive pulmonary disease（ COPD） patients. Methods 34 cases of COPD patients with acute aggravating period,34 cases of COPD patients with plateau and 34 cases of healthy volunteers were selected,and they were divided into acute group,stable group,control group respectively. The serum IL- 6,hs- CRP,IL- 10 serum levels in groups,and the correlation of them with lung function was analyzed. Results The FEV1%,FEV1/FVC in acute group and stable group were significantly lower than the control group,and acute group were significantly lower than the stable group,the differences were statistically significant（ P 〈 0. 05）. The hs- CRP and IL- 6 in acute group and stable group were significantly higher than that of control group,and IL- 10 was significantly lower than the control group,and the hs- CRP in acute group was significantly higher while the IL- 10 was significantly lower than the stable group,with the differences statistically significant（ P 〈 0. 05）. Pearson correlation analysis showed that serum IL- 6,hs- CRP were significantly negative correlated to FEV1%,FEV1/FVC（ r =- 0. 221,- 0. 216,- 0. 386,- 0. 369,P 〈 0. 05）,while IL- 10 was significantly positively related to FEV1%,FEV1/FVC in COPD patients（ r = 0. 318,0. 297,P 〈 0. 05）. Conclusion IL- 6,hs- CRP,IL- 10 are involved in the pathogenesis of COPD,and they can reflect the severity of the disease to a certain extent.