乙型肝炎疫苗接种对乙型肝炎血清标记物测定结果影响的对比分析

Comparative analysis of the effect of hepatitis B vaccine inoculation on the determination results of hepatitis B serum markers

目的了解昌吉地区乙型肝炎疫苗的预防接种对乙型肝炎血清标记物测定结果的影响,为乙型肝炎疫苗的长期接种提供科学依据。方法收集1995年新疆昌吉市某中学1 028名13岁～18岁的在校学生乙型肝炎血清标记物测定结果的资料,2015年本实验室又对该中学1656名曾接种过乙型肝炎疫苗的学生,采用酶联免疫吸附试验（ELISA）进行了乙型肝炎血清标记物测定,用描述流行病学方法对前后2次乙型肝炎检测资料进行统计。结果 2次检测都是以乙型肝炎5项全部阴性百分比最高,分别为58.95%和48.97%。1995年HBsAg阳性率明显高于2015年,差异有统计学意义（P〈0.01）;2015年HBsAb阳性率明显高于1995年,差异有统计学意义（P〈0.01）;结论乙型肝炎疫苗有效的预防了乙型肝炎病毒的感染和传播。

Objective To understand the hepatitis B vaccine inoculation influence on the determination result of serum markers of hepatitis B in Changji area,so as to provide scientific basis for long- term project of hepatitis B vaccine immunization.Methods The detection data of marks were collected from 1 028 students aged 13- 18 in a middle school of Changji,Xinjiang in 1995. And in 2015,1 656 students from this school accepted hepatitis B vaccine for the detection of hepatitis B serum marker by enzyme linked immunosorbent assay（ ELISA）. Statistical methods were used to describe the epidemiological data of hepatitis B before and after. Results The two tests were negative with the highest percentage in all 5,accounting for 58. 95% and48. 97% respectively. And in 1995,the positive rate of HBsAg was significantly higher than that in 2015,with the difference statistically significant（ P〈 0. 01）; the positive rate of anti- HBS in 2005 was significantly higher than that in 1995,and the difference is statistically significant（ P〈 0. 01）. Conclusion Hepatitis B vaccine can effectively prevent infection and transmission of hepatitis B virus.