摘要
Twist是高度保守的碱性螺旋-环-螺旋转录因子,为新近发现的癌基因。Twist能够编码凋亡抑制蛋白,参与多种上皮来源肿瘤细胞的上皮间充质转化(EMT)过程,调控肿瘤血管、淋巴管的生成等过程,与肿瘤的侵袭、转移关系密切。目前已在多种肿瘤中发现Twist表达增高,开展Twist表达与肿瘤的侵袭转移关联性的研究对临床预防、治疗癌症转移意义重大。
Twist is a highly conserved basic helix-loop-helix transcription factor,which is considered as an oncogene recently. Twist gene is involved in encoding inhibition of apoptosis protein and promoting epithelial-mesenchymal transition（EMT） in cancer,and may participate in tumor invasion and metastasis,angiogenesis and lymphangiogenesis. Study on the association of Twist with tumor invasion and metastasis would be of value in clinical prevention and treatment of cancer metastasis.
作者
方雪妮
周天
李泉旺
胡凯文
FANG Xue-ni ZHOU Tian LI Quan-wang et al.(Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078)
出处
《中国肿瘤》
CAS
2016年第11期893-897,共5页
China Cancer
基金
国家自然科学基金(81403250)
