急性幕上性脑出血患者脑水肿体积与高迁移率族蛋白B1的关系

The preliminary study of association between serum HMGB1 levels and perihematoma edema volume after supratentorial intracerebral hemorrhage

目的探讨脑出血后高迁移率族蛋白B1(high mobility group protein B1,HMGB1)水平的变化及其与脑出血后继发性脑水肿的关系。方法收集152例幕上性脑出血患者的入院各基线资料及发病24 h时的HMGB1水平和发病后3或4 d复查头颅CT显示的相对水肿体积。结果初入院的HMGBl水平要显著高于对照组(P<0.05),且24 h患者HMGBl水平与第3或4 d CT复查显示的相对水肿体积呈正相关(r=0.87,P=0.001)。结论脑出血后HMGBl水平显著升高,且与脑水肿体积进展程度呈正相关。

ObjectiveTo investigate the changes of HMGB1 after cerebral hemorrhage and analyze the relationship between HMGB1 and cerebral hemorrhage secondary brain edema.Methods We collected 152 cases of acute spontaneous supratentorial intracerebral hemorrhage. All patients were measured serum HMGB1 levels within 6 hours and on 24 h after intracerebral hemorrhage. Then they were given a baseline computerized axial tomography（CT）scan within 6 hours after intracerebral hemorrhage, and review head CT 3 or 4 days later.To control for hematoma volume,the hematoma volume was subtracted from that of the absolute edema.Then the absolute edema volume was divided by the hematoma volume,to express perihematoma edema volume as a ratio of the associated hematoma volume（relative edema volume）.The collected results were analysised by SPSS 13.0 statistical software package.Correlations were determined using Spearman’s rank correlation coefficients.Results Compared with normal control, patients’ serum HMGB1 level had a significant increase within 6 hours（P〈0.05）. Furthmore, serum HMGB1 on 24 hours was correlated well with relative perihematoma edema volume on 3 to 4 days（r=0.87, P=0.001）.Conclusion This study provides evidence that serum HMGB1 levels were increased significantly after cerebral hemorrhage, and correlate with the relative perihematoma edema volume on 24 hours. This research can shed a light on evaluation and treatment of intracerebral hemorrhage.