旋覆花化学成分研究

Chemical Constituents of Inula japonica

目的:研究旋覆花的化学成分。方法:采用硅胶、Sephadex LH-20、MCI、半制备液相等色谱技术分离纯化,根据理化性质、质谱和核磁共振技术鉴定各化合物结构。结果:从旋覆花中分离得到14个化合物,分别鉴定为:ivangustin(1)、1-乙酰氧基大花旋覆花内酯(2)、1β-羟基-土木香内酯(3)、银胶菊素(4)、11,13-dihydroinuchinenolide B(5)、britanlin A(6)、vomifoliol(7)、17-hydroxy-16α-ent-kauran-19-oic acid(8)、12-hydroxygeranylgeraniol(9)、二氢槲皮素(10)、山柰酚(11)、槲皮素(12)、二氢松柏醇(13)、fareanol(14)。结论:其中,化合物5、6、9、13、14为首次从该植物中分离得到。

Objective： To study the chemical constituents of Inula japonica. Methods： Silica gel,Sephadex LH-20,MCI and semipreparative HPLC were used to isolate and purify the constituents of Inula japonica,and the chemical structures were elucidated by chemical properties,MS and NMR analysis. Results： 14 compounds were isolated and their structures were identified as ivangustin（ 1）,1-acetoxy-6α-hydroxyeriolanolide（ 2）,1β-hydroxyalantolactone（ 3）,tomentosin（ 4）,11,13-dihydroinuchinenolide B（ 5）,britanlin A（ 6）,vomifoliol（ 7）,17-hydroxy-16α-ent-kauran-19-oic acid（ 8）,12-hydroxygeranylgeraniol（ 9）,dihydroquercetin（ 10）,kaempferol（ 11）,quercetin（ 12）,dihydroconiferyl alcohol（ 13） and fareanol（ 14）. Conclusion： Compounds 5,6,9,13 and 14 are isolated from this plant for the first time.