慢性乙型肝炎病毒感染与听力相关性初步研究

A Preliminary Study on the Correction between Chronic Hepatitis B Virus Infection and Hearing Status

目的通过研究乙型肝炎病毒（HBV）感染者听力水平了解HBV对听力是否存在影响。方法对64名慢性HBV感染者（包括HBV携带者34例，慢性乙型肝炎患者30例）及46例对照者行纯音测听、声导抗测听等检查，并对平均听阂行统计分析。结果3组语频平均听阈（500、1000、2000Hz）比较，HBV携带组与对照组无统计学差异（P〉0．05），慢性乙肝组与对照组具有显著统计学差异（P〈0．01）。HBV携带组和对照组在500～8000Hz倍频听阈无统计学差异（P〉0．05），250Hz听阈差异有显著统计学意义（P〈0．01）。慢性乙肝组和对照组250～8000Hz各频率听阈差异均有统计学意义，其中250、2000、4000、8000Hz具有显著差异（P〈0．01）。结论HBV携带者听力水平除250HzPb与对照组均无统计学差异，而慢性乙肝患者各频率均出现听力下降。提示慢性乙肝患者可能存在内耳的感染及病变。

Objective This study was to investigate the relation between chronic hepatitis B virus infection and hearing status.Methods 64 hepatitis-B patients were recruited as the study group, including 34 HBV carriers and 30 chronic hepatitis B patients, and 46 normal cases as the control group. Pure tone audiometry and acoustic immittance were performed on the participants and a statistical analysis was used.Results The average hearing thresholds at 250 Hz showed significant differences between the control group and HBV Carriers （P〈0.01）. At 500 through 8000 Hz, the average hearing threshold of speech frequency （500, 1000, 2000 Hz）showedno statistical differences （P〉0.05）. The average hearing thresholds at 250- 8000 Hz and average hearing threshold of the speech frequency showed statistical differences between the control and the study groups （P〈0.05）. At 250, 2000, 4000,and 8000 Hz the difference was statistically significant （P〈0.01）.Conclusion There is no significant difference in the average hearing thresholds except for 250 Hz between the control group and HBV Carriers. The average hearing thresholds at each frequency for chronic hepatitis B virus showed decreases. This indicates the infection of the inner ear and the pathological changes of the patients.