妊娠期血栓高危患者的预防性抗凝治疗进展

Prophylactic anticoagulation for pregnant women with high risk of thrombosis

孕妇自身处于高凝状态,若合并易形成血栓的高危因素（常见的如心脏机械瓣置换术、系统性红斑狼疮、抗磷脂抗体综合征、妊娠期高血压疾病、肥胖）,常需使用肝素/华法林预防性抗凝治疗.由于肝素、华法林抗凝利弊,如何选择抗凝药物争议较大.本文将阐述常见血栓形成疾病预防用药现状及进展,分析华法林与肝素抗凝及抗凝药物的相关问题.

Pregnant women are usually in a hypercoagulable state;if it is complicated with high risk conditions of thrombosis,such as obesity,pregnancy-induced hypertension,mechanical heart valve replacement,systemic lupus erythematosus and antiphospholipid syndrome,prophylactic anticoagulation therapy with heparin/warfarin will be required.Due to pros and cons of heparin/warfarin,there is a controversy about how to choose anticoagulants.This article reviews the current status and progress of drug prophylaxis for thrombosis disease,and related issues particularly for administration of heparin and warfarin.