磺酸腺苷蛋氨酸治疗婴儿肝炎综合征临床研究

Clinical research on sulfonic acid adenosine methionine in treatment of infantile hepatitis syndrome

目的 观察磺酸腺苷蛋氨酸治疗婴儿肝炎综合症的临床疗效。方法 选择2013年5月~2016年2月在我科进行治疗的确诊为肝炎综合症的患儿84例,随机分为对照组和观察组各42例,两组的患儿均给予补液,补充维生素和营养支持等治疗,对照组的患儿给予抗病毒及熊去氧胆酸保肝利胆等治疗;观察组患儿在对照组治疗的基础上加用磺酸腺苷蛋氨酸治疗。结果 两组的ALT、AST、TBIL、DBIL在治疗后与治疗前相比较,均显著下降,差异有统计学意义（P〈0.05）,两组的ALT、AST、TBIL、DBIL治疗后组间相比较,观察组优于对照组（P〈0.05）。两组患儿的疾病疗效比较,观察优于对照组（P〈0.05）。结论 磺酸腺苷蛋氨酸治疗婴儿肝炎综合症的临床效果显著。

Objective To observe the clinical effect of sulfonic acid adenosine methionine in treatment of infantile hepatitis syndrome. Methods 84 cases of children diagnosed with hepatitis syndrome in our department from May 2013 to February 2016 were selected and randomly divided into control group and observation group with 42 cases in each.All children in the two groups were given fluid,vitamin and nutritional support and other treatment.Children in control group were treated with Antiviral and UDCA choleretic,and children in observation group were treated with sulfonic acid adenosine methionine on the basis of control group. Results ALT,AST,TBIL,DBIL of the two groups after the treatment were all significantly decreased,compared with those before the treatment.And there was statistical significance （P 〈 0.05）.ALT,AST,TBIL,DBIL of observation group were better than those of control group （P 〈 0.05）. Disease curative effect of observation group was better than that of control group （P 〈 0.05）. Conclusion The clinical effect of sulfonic acid adenosine methionine in treatment of infantile hepatitis syndrome is significant.