抗幽门螺杆菌的序贯治疗与传统治疗的疗效分析

Curative effect analysis of sequential therapy and traditional therapy in treatment of anti-Helicobacter pylori

目的 对于儿童幽门螺杆菌感染采用序贯治疗与传统治疗的效果进行对比。方法 选取我院2014年3月~2016年3月期间收治的经13C尿素呼气试验确诊为幽门螺杆菌阳性患儿126例进行研究,随机分为观察组与对照组,各63例,对照组采用传统三联疗法治疗,观察组采用序贯治疗法,对两组患儿治疗的效果进行对比。结果 经过治疗,从幽门螺杆菌根除率方面对比,观察组清除有效率为96.83%,对照组为79.37%,两组对比,观察组明显优于对照组,差异有统计学意义（P〈0.05）;从两组患儿不良反应发生情况对比,两组差异无统计学意义（P〉0.05）。结论 对于儿童幽门螺杆菌感染患儿而言,采用序贯治疗方法治疗效果较好,不良反应发生率低,在临床中值得推广应用。

Objective To compare the curative effect of sequential therapy and traditional therapy in treatment of anti-Helicobacter pylori. Methods 126 cases of helicobacter pylori positive patients diagnosed by 13C urea breathe test in our hospital from March 2014 to March 2016 were selected and randomly divided into observation group and control group with 63 cases in each. Patients in control group were treated with traditional triple therapy, and patients in observation group were treated with sequential therapy. Curative effects of the two groups were compared. Results After treatment, from the Comparison of the eradication rate of Helicobacter pylori, the effective rate of observation was 96.83%, the effective rate of control group was 79.37%, the observation group was significantly better than control group, and the difference was statistically significant （P 〈 0.05）. From the comparison of adverse reactions, the difference was not significant between the two groups with no statistical significance（P 〉 0.05）. Conclusion For children with Helicobacter pylori infection, the curative effect of sequential therapy was better, and its incidence of adverse reactions was low. It is worth popularizing in clinic.