急性冠状动脉综合征患者血清APN、HO-1、Ox-LDL水平与冠状病变程度的相关性分析

Correlation between serum APN、HO-1、Ox-LDL and severity of coronary artery stenosis in patients with acute coronary syndrome

目的 分析急性冠状动脉综合征（ACS）患者血清脂联素（APN）、血红素加氧酶-1（HO-1）、氧化修饰低密度脂蛋白（ox-LDL）水平与冠状病变程度的相关性。方法 纳入138例被怀疑有冠状动脉疾病的患者,经过冠状动脉照影术的检查并伴随心电图检测,将其分为ACS组78例、稳定型心绞痛（SAP）组41例和正常的冠状动脉组（NC）组19例;按照冠脉造影结果分为单支病变组28例,双支病变组39例,三支病变组52例。按照冠状动脉病变狭窄程度不同将ACS患者分为：病变狭窄程度≤50%组19例、51%-75%组20例、76%-90%组49例和91%-100%组50例。采用定量的酶联免疫法测定各组血清APN、HO-1、Ox-LDL水平。结果 ACS组和SAP组患者的血清APN、HO-1水平显著性低于对照组,而Ox-LDL水平显著性高于对照组;同时,ACS组患者的血清APN、HO-1水平显著性低于SAP组,而Ox-LDL水平显著性高于SAP组。三支病变组血清APN、HO-1水平显著性低于单支病变组及双支病变组,而Ox-LDL水平显著性高于单支病变组及双支病变组;双支病变组血清APN、HO-1水平显著性低于单支病变组,而Ox-LDL水平显著性高于单支病变组。病变狭窄程度91%-100%组和76%-90%组患者的血清APN、HO-1水平均显著性低于病变狭窄程度51%-75%和≤50%组的患者,而Ox-LDL水平则均显著性高于病变狭窄程度51%-75%和≤50%组的患者;病变狭窄程度51%-75%组患者的血清APN、HO-1水平显著性低于病变狭窄程度≤50%组的患者,而Ox-LDL水平则显著性高于病变狭窄程度≤50%组的患者。结论 ACS患者血清APN、HO-1、Ox-LDL水平与冠状病变程度密切相关,可作为ACS早期诊断的标记物。

Objective To analyze serum APN in patients with acute coronary syndrome, HO - 1, Ox - LDL levels and coronary lesion severity correlation. Methods The study included 138 cases suspected to have coronary artery disease, who were divided into ACS group （78 cases）, SAP group （41 cases） and NC group （ 19 cases） , according to coronary checked according to lithography and accompanied by ECG testing. According to coronary angiography results, they were divided into single -vessel disease group （28 cases）, double -vessel disease group （39 cases） , three - vessel disease group （52 cases）. According to the different degree of coronary artery stenosis, ACS patients were divided into stenosis ≤50% group （19 cases）, 51% ~75% group （20 cases）, 76% -90% group （49 cases） and 91% -100% group （50 cases）. The serum levels of APN, HO - 1 and Ox - LDL were measured by enzyme - linked immunosorbent assay （ELISA）. Results The serum APN, HO - 1 levels of ACS and SAP group were significantly lower than those of the control group, while the Ox - LDL levels were significantly higher than that of the control ; at the same time, the APN and HO - 1 levels of ACS group were significantly lower than that of the SAP group, and Ox - LDL levels were significantly higher than that of SAP group. The serum APN, HO - 1 levels of three - vessel disease group were significantly lower than those of single - vessel disease and two vessel disease, and Ox - LDL levels were significantly higher than those of single - vessel disease and two vessel disease; serum APN, HO - 1 levels of double - vessel disease group were significantly lower than those of single - vessel disease, the Ox - LDL levels were significantly higher than those of single - vessel disease. The patient＇s serum APN, HO - 1 of the degree of stenosis of 91% - 100% group and 76% -90% group were significantly lower than those of patients with stenosis of 51% - 75 % and the degree of ≤50% group and Ox - LDL levels were significantly higher than the degree of stenosis and 51% - 75 %, ≤ 50% group of patients; the degree of stenosis 75 % to 51% of patients with serum APN, HO - 1 levels were significantly lower than those of the degree of stenosis ~〈50% group, and Ox - LDL levels were significantly higher than those lesions ≤50% stenosis group. Conclusion Patients with acute coronary syndrome serum APN, HO - 1, Ox - LDL levels and coronary lesions are closely related, perhaps the indexes can be considered as an early diagnostic marker for ACS.