胆汁淤积性肝病的治疗被引量：7

Treatment of cholestastic liver disease

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摘要胆汁淤积性肝病是以胆汁淤积为主要表现的肝胆疾病总称，各种肝内外因素所致的胆汁流形成、分泌和排泄障碍均可导致胆汁淤积。根据病因，可将胆汁淤积性肝病分为肝细胞性胆汁淤积、胆管性胆汁淤积和混合性胆汁淤积，包括原发性胆汁性胆管炎（primary biliary cholangitis，PBC）、原发性硬化性胆管炎（primary sclerosing cholangitis，PSC）、妊娠期肝内胆汁淤积症（intrahepatic cholestasis of pregnancy，ICP）、良性复发性肝内胆汁淤积（benign recurrent intrahepatic cholestasis，BRIC）、进行性家族性肝内胆汁淤积（progressive familial intrahepatic cholestasis，PFIC）等。

作者阎俪马雄

机构地区交通大学医学院附属仁济医院消化科/上海市消化疾病研究所

出处《实用肝脏病杂志》 CAS 2016年第6期650-653,共4页 Journal of Practical Hepatology

关键词胆汁淤积性肝病胆汁性胆管炎硬化性胆管炎治疗 Cholestatic liver disease Biliary cholangitis Sclerosing cholangitis Treatment

分类号 R575 [医药卫生—消化系统]

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1Dong M,Li J,Tang R,et al. Multiple genetic variants associated with primary biliary cirrhosis in a Han Chinese population[J]. Clin Rev Allergy Immunol,2015,48(2-3):316-321.
2Newton JL,Bhala N,Burt J,et al. Characterisation of the associations and impact of symptoms in primary biliary cirrhosis using a disease specific quality of life measure. J Hepatol,2006,44(4):776-783.
3Quarneti C,Muratori P,Lalanne C,et al. Fatigue and pruritus at onset identify a more aggressive subset of primary biliary cirrhosis. Liver Int,2015,35(2):636-641.
4Beuers U,Kremer A E,Bolier R,et al. Pruritus in cholestasis: facts and fiction. Hepatology,2014,60(1):399-407.
5Yang CY,Ma X,Tsuneyama K,et al. IL-12/Th1 and IL-23/Th17 biliary microenvironment in primary biliary cirrhosis: Implications for therapy. Hepatology,2014,59(5):1944-1953.
6Shi J,Wu C,Lin Y,et al. Long-term effects of mid-dose ursodeoxycholic acid in primary biliary cirrhosis:a meta-analysis of randomized controlled trials. Am J Gastroenterol,2006,101(7):1529-1538.
7Zhang Y,Li S,He L,et al. Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy:a meta-analysis. Drug Des Devel Ther,2015,9:2757-2766.
8Yin Q,Li J,Xia Y,et al. Systematic review and meta-analysis:bezafibrate in patients with primary biliary cirrhosis. Drug Design,Develop Ther,2015,9:5407.
9Rautiainen H,Karkkainen P,Karvonen AL,et al. Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis:a three-year randomized trial. Hepatology,2005,41(4):747-752.
10Hirschfield G M,Mason A,Luketic V,et al. Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid. Gastroenterology,2015,148(4):751-761. e8.