心理应激与非酒精性脂肪性肝病

Psychological stress in nonalcoholic fatty liver diseases

非酒精性脂肪性肝病(NAFLD)主要由多吃少动的生活方式引起,但这难以解释非肥胖NAFLD的发病,因此可能存在其它的病因及机制,已成为近来研究的新方向。另外,NAFLD患者难以坚持良好的生活习惯使制定更全面有效的治疗方案成了另一热点。本文对心理应激、抑郁、焦虑情绪、下丘脑-垂体-肾上腺(HPA)轴失衡、糖脂代谢紊乱以及免疫炎症反应在NAFLD发展中的作用进行了介绍。

Nonalcoholic fatty liver disease （NAFLD） is thought to be mainly caused by over-eating and sedentary lifestyle, while it can hardly explain the incidence of non-obese NAFLD. Recently,other possible causes and mechanisms has become a new research spot. It’s very hard for a patient with NAFLD to stick to a well-designed living regimen,so giving an overall and more effective treatment has now become another hotspot. This article reviewed the psychological stress,emotions,such as depression and anxiety,imbalance of hypothalamic-pituitary-adrenal （HPA） axis,glucose and lipid metabolism disorders, and immuno-inflammatory responses in the development of NAFLD.