丙戊酸钠对比苯妥英钠治疗癫痫效果分析

Analysis of the effect of sodium valproate and phenytoin contrast treatment of epilepsy

目的对比丙戊酸钠与苯妥英钠治疗癫痫的临床效果。方法 选择2013年3月～2016年2月我院神经内科收治的发作类型为强直-阵挛发作的癫痫患者62例为研究对象,随机分为甲组31例、乙组31例。甲组予丙戊酸钠治疗,乙组予苯妥英钠治疗,观察两组患者的疗效和不良反应。结果 甲组总有效率为80.65%,乙组总有效率为77.42%;甲组不良反应发生率为9.69%,乙组不良反应发生率为12.91%。两组疗效、不良反应发生率差异均无统计学意义（P〉0.05）。结论 丙戊酸钠、苯妥英钠治疗发作类型为强直-阵挛发作的癫痫效果均较好,两药疗效、不良反应发生率无明显差异。

Objective To compare the clinical effect of sodium valproate and phenytoin in the treatment of epilepsy. Methods A total of 62 cases of the patients with epilepsy seizures tonic clonic seizures of Department of Neurology of our hospital from March 2013 to February 2016 were randomly divided into group A and group B, each of 31 cases. Group A took valproatc treatment, group B took phenytoin treatment, the curative effect and adverse reaction of two groups of patients were observed. Results The total effective rate was 80.65% in group A; the total effective rate was 77.42% in group B; the incidence rate of adverse reaction was 9.69% in group A; the incidence of adverse reactions was 12.91% in group B. There was no significant difference in the curative effect and adverse reaction rate between the two groups （P〉0.05）. Conclusion The effect of sodium valproate and phenytoin for epilepsy seizures tonic clonic seizures is good; The curative effect and adverse reaction rate of the two drugs have no obvious difference.