噻托溴铵对稳定期慢性阻塞性肺疾病患者肺功能的影响

Influence by tiotropium bromide on pulmonary function in chronic obstructive pulmonary disease patients

目的探讨噻托溴氨对稳定期慢性阻塞性肺疾病患者肺功能的影响。方法 40例稳定期慢性阻塞性肺疾病患者,随机分为试验组和对照组,各20例。对照组采用口服氨茶碱缓释片进行治疗,试验组采用噻托溴铵进行治疗,比较两组患者的肺功能。结果治疗后试验组第1秒用力呼气容积(FEV1)/用力肺活量(FVC)为(68.21±6.13)%优于对照组的(62.51±6.69)%,差异有统计学意义(P<0.05)。治疗后试验组FEV1/预计值为(71.62±6.72)%优于对照组的(64.52±6.65)%,差异有统计学意义(P<0.05)。结论使用噻托溴铵对稳定期慢性阻塞性肺疾病患者进行治疗,可以明显提高患者的肺功能,值得在临床推广。

Objective To investigate influence by tiotropium bromide on pulmonary function in chronic obstructive pulmonary disease patients. Methods A total of 40 patients with stable chronic obstructive pulmonary disease were randomly divided into experimental group and control group, with 20 cases in each group. The control group received oral administration of aminophylline sustained release tablets for treatment, while the experimental group received tiotropium bromide instead. Comparison was made on pulmonary function between the two groups. Results After treatment, the experimental group had better forced expiratory volume in 1 second（FEV1）/forced vital capacity（FVC） as（68.21±6.13）% than（62.51±6.69）% in the control group. Their difference had statistical significance（P〈0.05）. The experimental group also had better FEV1/predicted value as（71.62±6.72）% than（64.52±6.65）% in the control group after treatment, and the difference had statistical significance（P〈0.05）. Conclusion Implement of tiotropium bromide in treating patients with stable chronic obstructive pulmonary disease can remarkably improve pulmonary function in patients, and this method is worth clinical promotion.