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玉屏风颗粒对儿童肾病综合征患者免疫功能的影响 被引量:10

The effect of Yupingfeng granules on immunologic function of childhood primary nephrotic syndrome
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摘要 目的探讨玉屏风颗粒对儿童原发性肾病综合征(PNS)免疫功能的影响。方法选取首次确诊为肾病综合征的患儿60例,随机分为玉屏风组和对照组,各30例。玉屏风组给予糖皮质激素联合玉屏风颗粒,对照组单用糖皮质激素,观察比较两组患儿感染率、复发率、糖皮质激素用量及外周T淋巴细胞亚群,血清IgG、IgA、IgM,补体C3、C4的水平。结果玉屏风组感染率和复发率均低于对照组(P<0.05);4个月时玉屏风组每日糖皮质激素用量小于对照组(P<0.05);玉屏风组CD3^+细胞比率、CD4^+细胞比率、CD8^+细胞比率及CD4^+/CD8^+比值均高于治疗前(P<0.01),且高于对照组治疗后(P<0.05);玉屏风组血清IgG、IgA、IgM,补体C3、C4水平高于对照组(P<0.05)。结论玉屏风颗粒可提高原发性肾病综合征患儿的免疫水平,控制感染及复发,减少糖皮质激素用量,安全可靠,值得推广。 Objective To study the effect of Yupingfeng granules on immunologic function of childhood primary nephrotic syndrome. Methods Patients who were first admitted and diagnosed as childhood primary nephrotic syndrome ( n = 60) were randomized into Yupingfeng group and control group, 30 case in each group. The patients of Yupingfeng group were treated with Yupingfeng granules plus glucocorticoid. The patients of control group were only treated with glucocorticoid. The two groups were compared for incidence of infection, replase rate, dosage of glucocorticoid, influence of T cell lymphocyte subpopulation, level of serum IgG, IgA, IgM and alexin C3, CA. Results The Yupingfeng group had significantly lower incidence of infection, replase rate and daily dose of glucocortieoid ( at month 4) than the control group ( P 〈 0. 05 ). The Yupingfeng group had significantly higher levels of T cell CD3 + , CD 4 + , CD 8 + and CD 4 +/CD 8 + than the levels of prior treatment (P 〈 0.01 ) , and had significantly higher level than the level of post treatment of the control group ( P 〈 0. 05 ). The Ynpingfeng group had significantly higher levels of IgG, IgA, IgM and alexin C3, C4 than the control group (P 〈 0. 05 ). Conclusion Yupingfeng granules treatment can improve the immune state of childhood primary nephrotic syndrome, control incidence of infection, replase rate and reduce daily dose of glucocorticoid. It has a favourable safety and worth to he popularized.
作者 李晓妍 王华
出处 《河南医学研究》 CAS 2016年第11期1927-1929,共3页 Henan Medical Research
关键词 玉屏风颗粒 肾病综合征 感染 免疫 儿童 Yupingfeng granules nephrotic syndrome infection immunity child
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