中药有效成分治疗肝损伤及肝纤维化作用机制的研究进展

Protective effects of Chinese traditional medicine against liver injury and liver fibrosis and mechanisms involved

肝损伤和肝纤维化是临床多发病和常见病,目前现代医学缺乏较为理想的治疗药物.近年研究表明多种中药有效成分对于肝损伤和肝纤维化具有一定的预防和治疗作用,作用机制与保护肝细胞、抗氧化以及抗炎相关.本文对中药有效成分抗肝损伤和抗肝纤维化的作用及机制进行总结,期望对预防和治疗肝损伤和肝纤维化以及治疗药物的研发起到一定的推动作用.

Liver injury and liver fibrosis are clinically common,and there is currently a lack of ideal drugs for these conditions.Recent studies have indicated that the effective components of traditional Chinese medicine show certain efficacy in prevention and treatment of liver injury and liver fibrosis,and the mechanisms are related to the protection of liver cells,antioxidation and anti-inflammation.This paper discusses the protective effects of the effective components of traditional Chinese medicine against liver injury and liver fibrosis and the mechanisms involved,with an aim to promote the development of therapeutic drugs for liver injury and liver fibrosis.