网络成瘾青少年静息态功能MRI区域一致性研究

Regional homogeneity in internet addiction adolescents：a resting-state functional MRI

目的：研究网络成瘾（IA）青少年静息态fMRI（rs-fMRI）局部一致性（ReHo）改变。方法2014年10月至2015年8月收集年龄、性别及教育程度相匹配的网络成瘾青少年12例（网络成瘾组）和正常对照组12名，所有受试者均完成简易精神状态检查量表（MMSE）评分。采用rs-fMRI分析受试者全脑静息态的ReHo，两组间比较采用独立样本t检验，并将两组间差异有统计学意义的脑区与网络依赖程度（每周上网时间）进行线性相关分析。结果与正常对照组相比，网络成瘾组MMSE评分差异无统计学意义，每周上网时间明显增多，差异有统计学意义（t=25.620，P〈0.01）。网络成瘾组左侧中央后回（体素129个，t=4.45）、左侧顶下小叶（体素156个，t=5.02）和左侧额叶下回（体素117个，t=4.14）ReHo值减低（P值均〈0.01），未发现ReHo值升高的脑区。相关分析显示左侧顶叶中央后回、顶下小叶及额叶额下回ReHo值与网络成瘾组青少年每周上网时间呈负相关（r值分别为-0.874、-0.746、-0.695，P值均〈0.05）。结论网络成瘾青少年存在多处脑区ReHo改变，且与网络依赖程度相关。

Objective To investigate the regional homogeneity （ReHo） changes of internet addiction （IA） adolescents using resting-state fMRI. Methods Twelve internet addiction adolescents and 12 healthy volunteers matched with age, gender and education level were collected from capital institute of pediatrics from October 2014 to August 2015. Mini-mental state examination was done for all subjects. Regional homogeneity of rs-fMRI were evaluated and compared between the two groups by using independent sample t-test. The correlation between ReHo values in different brain regions and hours spent online per week of the IA group was analyzed. Results Compared with normal controls, the adolescents with IA showed significant increased hours online per week （P〈0.01）. They also showed significant decreased ReHo in the left postcentral gyrus （129 voxels, t=4.45）, left inferior parietal lobule （156 voxels, t=5.02） and left inferior frontal gyrus （117 voxels, t=4.14）. No increased ReHo region was found in the whole brain. The correlation analysis showed negative correlation between the hours spent online per week and the ReHo values of the left postcentral gyrus（r=-0.874,P〈0.05）, left inferior parietal lobule（r=-0.746,P〈0.05）, and left inferior frontal gyrus（r=-0.695,P〈0.05）. Conclusion Adolescents with internet addiction have great ReHo alterations in many brain regions, which were linked to the degree of internet dependency.