血清降钙素原检测在慢性阻塞性肺疾病急性加重期患者抗感染治疗中的价值

Anti-infection study of serum procalcitonin detection in patients with acute exacerbation of chronic obstructive pulmonary disease

目的：探讨血清降钙素原检测在慢性阻塞性肺疾病急性加重期患者中的抗感染意义。方法：随机选取来某院就诊的慢性阻塞性肺疾病急性加重期（AECOPD）吸烟患者100例,分为观察组与对照组,各50例。对照组由患者临床症状表现指导应用抗生素,观察组由血清PCT的检测水平指导应用抗生素,比较2组患者的抗生素使用情况及治疗后2组患者的各项指标。结果：观察组患者抗生素使用时间多为7-10 d,而对照组患者抗生素使用时间多大于10 d,观察组抗生素使用率（66.0%）低于对照组（94.0%）,治疗后观察组CRP（C反应蛋白）、白细胞计数少于对照组,住院天数短于对照组,差异有统计学意义（P〈0.05）。结论：在AECOPD患者的抗感染治疗中通过检测血清PCT水平可指导科学合理的应用抗生素,靶向性强,能有效控制患者抗生素使用时间,明显改善患者肺功能状况,有效促进患者早日康复。

Objective： To assess the anti-infection effect of serum procalcitonin detection in patients with acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）. Methods： 100 smoking AECOPD patients were selected in the study,and randomly divided into 2 groups. The control group（ n = 50） was treated with antibiotics by the guidance of clinical symptoms and the experimental group（ n = 50） was treated with antibiotics directed by serum PCT levels. Then status of antibiotic use and indexes of the 2 groups were compared. Results： The cure time in the experimental group（ mostly 7 - 10 d） was shorter than that of the control group（ mostly over10d）. The usage rate of antibiotics in the experimental group（ 66. 0%） was lower than the control group（ 94. 0%）. Besides,the experimental group had a lower CRP and white blood cell count and a shorter hospitalization than the control group. The differences were significant（ P〈0. 05）. Conclusion： Detection of serum PCT level in anti-infection treatment of patients with AECOPD may contribute to a more scientific and rational use of antibiotics and more precise targeting. It can significantly improve patients＇ pulmonary function and effectively promote patients＇ recovery.