摘要
目的:观察海桐皮汤熏洗配合局部涂擦七珠展筋散治疗膝骨关节炎的临床疗效。方法:将70例膝骨关节炎患者随机分为治疗组和对照组,每组35例。对照组给予膝关节腔局部注射玻璃酸钠配合口服洛索洛芬钠片治疗,治疗组在膝关节腔局部注射玻璃酸钠基础上,采用海桐皮汤熏洗患膝,配合七珠展筋散局部揉药进行治疗。2组均治疗3周。观察2组临床疗效及治疗前后疼痛视觉模拟评分法(VAS)评分、红细胞沉降率、C-反应蛋白,并观察2组不良反应。结果:治疗组临床控制5例,显效9例,有效18例,无效3例,总有效率为91.43%;对照组临床控制3例,显效8例,有效16例,无效8例,总有效率为77.14%。2组比较,差异有统计学意义(P<0.05)。治疗后,2组VAS评分较治疗前均有明显改善(P<0.05),且治疗组优于对照组(P<0.05);2组红细胞沉降率和C-反应蛋白较治疗前均下降,但差异无统计学意义(P>0.05)。对照组因口服洛索洛芬钠片有3例患者出现轻微恶心、呕吐、腹痛等不良反应,而治疗组未出现不良反应。结论:采用海桐皮汤熏洗配合局部七珠展筋散揉药治疗早、中期膝骨关节炎,可明显改善患者症状、体征,临床疗效确切,且操作方便,临床安全性高。
Objective:To observe the curative effect of fumigation and washing therapy with Haitongpi Decoction ( 海桐皮汤 ) combined with local application of Qizhu Zhanjin San ( 七珠展筋散 ) in the treatment of knee osteoarthritis.Methods:Seventy cases of knee osteoarthritis were randomly divided into two groups:a treatment group and a control group,35 cases in each group.The control group was given local injection of hyaluronate sodium into knee joint cavity combined with oral administration of Loxoprofen Sodium Tablets,while the treatment group,after being given local injection of hyaluronate sodium into knee joint cavity, was further treated with fumigation and washing with Haitongpi Decoction and rubbing treatment with Qizhu Zhanjin San.The 2 groups were treated for 3 weeks.The clinical efficacy, adverse reactions and VAS score,erythrocyte sedimentation rate and C-reactive protein before and after treatment were observed.Results:In the treatment group,5 cases were clinically controlled,9 cases were markedly effective, 18 cases were effective,3 cases were ineffective,and the total effective rate was 91.43%;while in the control group,3 cases was clinically controlled,8 cases were markedly effective,16 cases were effective,8 cases were ineffective,and the total effective rate was 77.14%.The difference was statistically significant between the 2 groups ( P 〈 0.05 ) .After treatment,the VAS scores of the 2 groups were significantly improved compared with those before treatment ( P 〈 0.05 ) ,and the treatment group was better than the control group ( P 〈 0.05 ) ;the erythrocyte sedimentation rate and C-reactive protein of the 2 groups were decreased compared with those before treatment,but the difference was not statistically significant ( P 〉 0.05 ) .In the control group,there were 3 cases with mild nausea,vomiting,abdominal pain and other adverse reactions due to oral administration of Loxoprofen Sodium Tablets,while there were no adverse reactions in the treatment group. Conclusion:Fumigation and washing with Haitongpi Decoction combining rubbing treatment with Qizhu Zhanjin San can significantly improve patients' symptoms and signs in the treatment of early-phase and metaphase knee osteoarthritis,clinically effective,convenient and safe.
作者
崔树平
李果
徐晓刚
CUI Shu-ping Ll Guo XU Xiao-gang
出处
《风湿病与关节炎》
2016年第11期37-40,共4页
Rheumatism and Arthritis
关键词
骨关节炎
膝
海桐皮汤
七珠展筋散
熏洗疗法
不良反应
osteoarthritis,knee
Haitongpi Decoction (海桐皮汤)
Qizhu Zhanjin San ( 七珠展筋散 )
fumigation and washing therapy
adverse reactions