32例活动期寻常型天疱疮患者血清免疫球蛋白G4水平分析

Serum Immunoglobulin G4 Level in 32 Patients with Active-phase Pemphigus Vulgaris

目的通过检测活动期寻常型天疱疮(PV)患者血清免疫球蛋白(Ig)G4浓度,了解IgG4在活动期PV患者血清中的水平。方法收集2014年4月-12月处于活动期(包括急性起始阶段和慢性活动期)的PV患者血清,通过免疫散射比浊法测定其血清IgG4水平,并比较PV患者和正常人群、急性起始阶段和慢性活动期患者间血清IgG4水平的差异。结果入选了32例活动期PV患者,血清IgG4在正常范围内的患者共有22例,其中男8例,女14例;IgG4升高8例,男3例,女5例;血清IgG4水平下降2例,男女各1例。32例患者与正常人群血清IgG4水平平均值比较,差异无统计学意义(P>0.05)。急性起始阶段PV患者血清IgG4浓度为(1.015±0.825)g/L,慢性活动期PV患者血清IgG4浓度为(1.058±1.133)g/L,两组间比较差异无统计学意义(P>0.05)。结论活动期PV患者的血清IgG4水平可以在正常范围内,也可以升高或降低;而IgG4水平在急性起始阶段和慢性活动期无明显变化。

ObjectiveTo learn the serum immunoglobulin G4 （IgG4） level in patients with pemphigus vulgaris （PV） in the active phase by detecting the IgG4 concentration in the patients with PV. MethodsWe collected the serum samples from patients with active-phase PV （including acute-onset and chronic active phases） between April and December 2014. The serum IgG4 level was detected by immuno-scatter turbidmetry, and the difference of serum IgG4 level between PV patients and normal subjects was assessed by Student＇s t-test. ResultsThirty-two patients with pemphigus vulgaris in the active phase were enrolled for this study, among whom 22 （including 8 males and 14 females） had normal serum IgG4 level, 8 （including 3 males and 5 females） higher and 2 （including 1 male and 1 female） lower. Compared with normal subjects, the average level of serum IgG4 in PV patients was not significantly different （P〉0.05）. The serum IgG4 level of acute-onset and chronic active PV patients was （1.015±0.825） g/L and （1.058±1.133） g/L, respectively, with no significant difference （P〉0.05）. ConclusionThe serum IgG4 level of patients with pemphigus vulgaris in the active phase can be normal, higher or lower. And there is no obvious difference in the serum IgG4 level between acute-onset and chronic active PV patients.